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10.3390/vaccines9020132 http://scihub22266oqcxt.onion/10.3390/vaccines9020132 33562141!7914464!33562141     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Vaccines+(Basel) 2021 ; 9 (2): ä Nephropedia Template TP {{tp|p=33562141|t=2021. Localized and Systemic Immune Responses against SARS-CoV-2 Following Mucosal Immunization |pdf=|usr=}}{{33562141}} gab.com Text Localized and Systemic Immune Responses against SARS-CoV-2 Following Mucosal Immunization JO: Vaccines (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=33562141 #FOAvip The rapid transmission of SARS-CoV-2 in the USA and worldwide necessitates the development of multiple vaccines to combat the COVID-19 global pandemic. Previously, we showed that a particulate adjuvant system, quil-A-loaded chitosan (QAC) nanoparticles, can elicit robust immunity combined with plasmid vaccines when used against avian coronavirus. Here, we report on the immune responses elicited by mucosal homologous plasmid and a heterologous immunization strategy using a plasmid vaccine and a Modified Vaccinia Ankara (MVA) expressing SARS-CoV-2 spike (S) and nucleocapsid (N) antigens. Only the heterologous intranasal immunization strategy elicited neutralizing antibodies against SARS-CoV-2 in serum and bronchoalveolar lavage of mice, suggesting a protective vaccine. The same prime/boost strategy led to the induction of type 1 and type 17 T-cell responses and polyfunctional T-cells expressing multiple type 1 cytokines (e.g., IFN-gamma, TNFalpha, IL-2) in the lungs and spleens of vaccinated mice. In contrast, the plasmid homologous vaccine strategy led to the induction of local mono and polyfunctional T-cells secreting IFN-gamma. Outcomes of this study support the potential of QAC-nano vaccines to elicit significant mucosal immune responses against respiratory coronaviruses. Twit Text FOAVip Localized and Systemic Immune Responses against SARS-CoV-2 Following Mucosal Immunization ????Vaccines (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=33562141 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33562141 #FOAvip English Wikipedia <ref>{{Cite pmid|33562141}}</ref> Localized and Systemic Immune Responses against SARS-CoV-2 Following Mucosal Immunization #MMPMID33562141 Chandrasekar SS; Phanse Y; Hildebrand RE; Hanafy M; Wu CW; Hansen CH; Osorio JE; Suresh M; Talaat AM Vaccines (Basel) 2021[Feb]; 9 (2): ä PMID33562141show ga The rapid transmission of SARS-CoV-2 in the USA and worldwide necessitates the development of multiple vaccines to combat the COVID-19 global pandemic. Previously, we showed that a particulate adjuvant system, quil-A-loaded chitosan (QAC) nanoparticles, can elicit robust immunity combined with plasmid vaccines when used against avian coronavirus. Here, we report on the immune responses elicited by mucosal homologous plasmid and a heterologous immunization strategy using a plasmid vaccine and a Modified Vaccinia Ankara (MVA) expressing SARS-CoV-2 spike (S) and nucleocapsid (N) antigens. Only the heterologous intranasal immunization strategy elicited neutralizing antibodies against SARS-CoV-2 in serum and bronchoalveolar lavage of mice, suggesting a protective vaccine. The same prime/boost strategy led to the induction of type 1 and type 17 T-cell responses and polyfunctional T-cells expressing multiple type 1 cytokines (e.g., IFN-gamma, TNFalpha, IL-2) in the lungs and spleens of vaccinated mice. In contrast, the plasmid homologous vaccine strategy led to the induction of local mono and polyfunctional T-cells secreting IFN-gamma. Outcomes of this study support the potential of QAC-nano vaccines to elicit significant mucosal immune responses against respiratory coronaviruses. äLocalized and Systemic Immune Responses against SARS-CoV-2 Following M(epmc).pdf DeepDyve Pubget Overpricing