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10.1038/s41586-021-03312-w http://scihub22266oqcxt.onion/10.1038/s41586-021-03312-w 33561864!7979515!33561864     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nature 2021 ; 591 (7850): 451-457 Nephropedia Template TP {{tp|p=33561864|t=2021. SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801 |pdf=|usr=}}{{33561864}} gab.com Text SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801 JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=33561864 #FOAvip All coronaviruses known to have recently emerged as human pathogens probably originated in bats(1). Here we use a single experimental platform based on immunodeficient mice implanted with human lung tissue (hereafter, human lung-only mice (LoM)) to demonstrate the efficient in vivo replication of severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as well as two endogenous SARS-like bat coronaviruses that show potential for emergence as human pathogens. Virus replication in this model occurs in bona fide human lung tissue and does not require any type of adaptation of the virus or the host. Our results indicate that bats contain endogenous coronaviruses that are capable of direct transmission to humans. Our detailed analysis of in vivo infection with SARS-CoV-2 in human lung tissue from LoM showed a predominant infection of human lung epithelial cells, including type-2 pneumocytes that are present in alveoli and ciliated airway cells. Acute infection with SARS-CoV-2 was highly cytopathic and induced a robust and sustained type-I interferon and inflammatory cytokine and chemokine response. Finally, we evaluated a therapeutic and pre-exposure prophylaxis strategy for SARS-CoV-2 infection. Our results show that therapeutic and prophylactic administration of EIDD-2801-an oral broad-spectrum antiviral agent that is currently in phase II/III clinical trials-markedly inhibited SARS-CoV-2 replication in vivo, and thus has considerable potential for the prevention and treatment of COVID-19. Twit Text FOAVip SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801 ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=33561864 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33561864 #FOAvip English Wikipedia <ref>{{Cite pmid|33561864}}</ref> SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801 #MMPMID33561864 Wahl A; Gralinski LE; Johnson CE; Yao W; Kovarova M; Dinnon KH 3rd; Liu H; Madden VJ; Krzystek HM; De C; White KK; Gully K; Schafer A; Zaman T; Leist SR; Grant PO; Bluemling GR; Kolykhalov AA; Natchus MG; Askin FB; Painter G; Browne EP; Jones CD; Pickles RJ; Baric RS; Garcia JV Nature 2021[Mar]; 591 (7850): 451-457 PMID33561864show ga All coronaviruses known to have recently emerged as human pathogens probably originated in bats(1). Here we use a single experimental platform based on immunodeficient mice implanted with human lung tissue (hereafter, human lung-only mice (LoM)) to demonstrate the efficient in vivo replication of severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as well as two endogenous SARS-like bat coronaviruses that show potential for emergence as human pathogens. Virus replication in this model occurs in bona fide human lung tissue and does not require any type of adaptation of the virus or the host. Our results indicate that bats contain endogenous coronaviruses that are capable of direct transmission to humans. Our detailed analysis of in vivo infection with SARS-CoV-2 in human lung tissue from LoM showed a predominant infection of human lung epithelial cells, including type-2 pneumocytes that are present in alveoli and ciliated airway cells. Acute infection with SARS-CoV-2 was highly cytopathic and induced a robust and sustained type-I interferon and inflammatory cytokine and chemokine response. Finally, we evaluated a therapeutic and pre-exposure prophylaxis strategy for SARS-CoV-2 infection. Our results show that therapeutic and prophylactic administration of EIDD-2801-an oral broad-spectrum antiviral agent that is currently in phase II/III clinical trials-markedly inhibited SARS-CoV-2 replication in vivo, and thus has considerable potential for the prevention and treatment of COVID-19. |*COVID-19 Drug Treatment[MESH] |Administration, Oral[MESH] |Alveolar Epithelial Cells/immunology/pathology/virology[MESH] |Animals[MESH] |COVID-19/immunology/*prevention & control[MESH] |Chemoprevention[MESH] |Chiroptera/virology[MESH] |Clinical Trials, Phase II as Topic[MESH] |Clinical Trials, Phase III as Topic[MESH] |Cytidine/administration & dosage/*analogs & derivatives/therapeutic use[MESH] |Cytokines/immunology[MESH] |Epithelial Cells/virology[MESH] |Female[MESH] |Heterografts[MESH] |Humans[MESH] |Hydroxylamines/*administration & dosage/*therapeutic use[MESH] |Immunity, Innate[MESH] |Interferon Type I/immunology[MESH] |Lung Transplantation[MESH] |Lung/immunology/pathology/virology[MESH] |Male[MESH] |Mice[MESH] |Post-Exposure Prophylaxis[MESH] |Pre-Exposure Prophylaxis[MESH] |SARS-CoV-2/immunology/pathogenicity[MESH]SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801(epmc).pdf DeepDyve Pubget Overpricing