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10.1152/ajplung.00552.2020

http://scihub22266oqcxt.onion/10.1152/ajplung.00552.2020
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33561380!8384564!33561380
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suck abstract from ncbi


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pmid33561380      Am+J+Physiol+Lung+Cell+Mol+Physiol 2021 ; 320 (5): L750-L756
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  • Carrageenan-containing over-the-counter nasal and oral sprays inhibit SARS-CoV-2 infection of airway epithelial cultures #MMPMID33561380
  • Schutz D; Conzelmann C; Fois G; Gross R; Weil T; Wettstein L; Stenger S; Zelikin A; Hoffmann TK; Frick M; Muller JA; Munch J
  • Am J Physiol Lung Cell Mol Physiol 2021[May]; 320 (5): L750-L756 PMID33561380show ga
  • Pharmaceutical interventions are urgently needed to prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and transmission. As SARS-CoV-2 infects and spreads via the nasopharyngeal airways, we analyzed the antiviral effect of selected nasal and oral sprays on virus infection in vitro. Two nose sprays showed virucidal activity but were cytotoxic precluding further analysis in cell culture. One nasal and one mouth spray suppressed SARS-CoV-2 infection of TMPRSS2-expressing Vero E6 cells and primary differentiated human airway epithelial cultures. The antiviral activity in both sprays could be attributed to polyanionic iota- and kappa-carrageenans. Thus, application of carrageenan-containing nasal and mouth sprays may reduce the risk of acquiring SARS-CoV-2 infection and may limit viral spread, warranting further clinical evaluation.
  • |*COVID-19 Drug Treatment[MESH]
  • |Adult[MESH]
  • |Animals[MESH]
  • |Antiviral Agents/*pharmacology[MESH]
  • |COVID-19/*prevention & control[MESH]
  • |Carrageenan/*pharmacology[MESH]
  • |Cell Line[MESH]
  • |Chlorocebus aethiops[MESH]
  • |Epithelial Cells/drug effects/virology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Nasal Sprays[MESH]
  • |Oral Sprays[MESH]
  • |SARS-CoV-2/*drug effects[MESH]
  • |Serine Endopeptidases/metabolism[MESH]


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