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10.1007/s00259-021-05219-0

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suck abstract from ncbi


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pmid33560453      Eur+J+Nucl+Med+Mol+Imaging 2021 ; 48 (9): 2871-2882
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  • Prevalence of interstitial pneumonia suggestive of COVID-19 at (18)F-FDG PET/CT in oncological asymptomatic patients in a high prevalence country during pandemic period: a national multi-centric retrospective study #MMPMID33560453
  • Albano D; Bertagna F; Alongi P; Baldari S; Baldoncini A; Bartolomei M; Boccaletto F; Boero M; Borsatti E; Bruno A; Burroni L; Capoccetti F; Castellani M; Cervino AR; Chierichetti F; Ciarmiello A; Corso A; Cuocolo A; De Rimini ML; Deandreis D; Dottorini ME; Esposito F; Farsad M; Gasparini M; Grana CM; Gregianin M; Guerra L; Loreti F; Lupi A; Martino G; Milan E; Modoni S; Morbelli S; Muni A; Nicolai E; Palumbo B; Papa S; Papaleo A; Pellerito R; Poti C; Romano P; Rossetti C; Rossini P; Rubini G; Ruffini L; Sacchetti G; Savelli G; Schiavariello S; Sciagra R; Sciuto R; Seregni E; Sestini S; Sicolo M; Spanu A; Storto G; Balducci MT; Trifiro G; Versari A; Vignati A; Volterrani D; Calcagni ML; Marzola MC; Garufo A; Evangelista L; Maroldi R; Schillaci O; Giubbini R
  • Eur J Nucl Med Mol Imaging 2021[Aug]; 48 (9): 2871-2882 PMID33560453show ga
  • PURPOSE: To assess the presence and pattern of incidental interstitial lung alterations suspicious of COVID-19 on fluorine-18-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) ([(18)F]FDG PET/CT) in asymptomatic oncological patients during the period of active COVID-19 in a country with high prevalence of the virus. METHODS: This is a multi-center retrospective observational study involving 59 Italian centers. We retrospectively reviewed the prevalence of interstitial pneumonia detected during the COVID period (between March 16 and 27, 2020) and compared to a pre-COVID period (January-February 2020) and a control time (in 2019). The diagnosis of interstitial pneumonia was done considering lung alterations of CT of PET. RESULTS: Overall, [(18)F]FDG PET/CT was performed on 4008 patients in the COVID period, 19,267 in the pre-COVID period, and 5513 in the control period. The rate of interstitial pneumonia suspicious for COVID-19 was significantly higher during the COVID period (7.1%) compared with that found in the pre-COVID (5.35%) and control periods (5.15%) (p < 0.001). Instead, no significant difference among pre-COVID and control periods was present. The prevalence of interstitial pneumonia detected at PET/CT was directly associated with geographic virus diffusion, with the higher rate in Northern Italy. Among 284 interstitial pneumonia detected during COVID period, 169 (59%) were FDG-avid (average SUVmax of 4.1). CONCLUSIONS: A significant increase of interstitial pneumonia incidentally detected with [(18)F]FDG PET/CT has been demonstrated during the COVID-19 pandemic. A majority of interstitial pneumonia were FDG-avid. Our results underlined the importance of paying attention to incidental CT findings of pneumonia detected at PET/CT, and these reports might help to recognize early COVID-19 cases guiding the subsequent management.
  • |*COVID-19[MESH]
  • |*Lung Diseases, Interstitial/diagnostic imaging/epidemiology[MESH]
  • |Fluorodeoxyglucose F18[MESH]
  • |Humans[MESH]
  • |Italy[MESH]
  • |Pandemics[MESH]
  • |Positron Emission Tomography Computed Tomography[MESH]
  • |Prevalence[MESH]
  • |Retrospective Studies[MESH]


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