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10.1210/clinem/dgab067 http://scihub22266oqcxt.onion/10.1210/clinem/dgab067 33560344!7928949!33560344     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Endocrinol+Metab 2021 ; 106 (5): 1255-1268 Nephropedia Template TP {{tp|p=33560344|t=2021. Association of Metformin with Susceptibility to COVID-19 in People with Type 2 Diabetes |pdf=|usr=}}{{33560344}} gab.com Text Association of Metformin with Susceptibility to COVID-19 in People with Type 2 Diabetes JO: J Clin Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=33560344 #FOAvip OBJECTIVE: Diabetes has emerged as an important risk factor for mortality from COVID-19. Metformin, the most commonly prescribed glucose-lowering agent, has been proposed to influence susceptibility to and outcomes of COVID-19 via multiple mechanisms. We investigated whether, in patients with diabetes, metformin is associated with susceptibility to COVID-19 and its outcomes. RESEARCH DESIGN AND METHODS: We performed a propensity score-matched cohort study with active comparators using a large UK primary care dataset. Adults with type 2 diabetes patients and a current prescription for metformin and other glucose-lowering agents (MF+) were compared to those with a current prescription for glucose-lowering agents that did not include metformin (MF-). Outcomes were confirmed COVID-19, suspected/confirmed COVID-19, and associated mortality. A negative control outcome analysis (back pain) was also performed. RESULTS: There were 29 558 and 10 271 patients in the MF+ and MF- groups, respectively, who met the inclusion criteria. In the propensity score-matched analysis, the adjusted hazard ratios for suspected/confirmed COVID-19, confirmed COVID-19, and COVID-19-related mortality were 0.85 (95% CI 0.67, 1.08), 0.80 (95% CI 0.49, 1.30), and 0.87 (95% CI 0.34, 2.20) respectively. The negative outcome control analysis did not suggest unobserved confounding. CONCLUSION: Current prescription of metformin was not associated with the risk of COVID-19 or COVID-19-related mortality. It is safe to continue prescribing metformin to improve glycemic control in patients with. Twit Text FOAVip Association of Metformin with Susceptibility to COVID-19 in People with Type 2 Diabetes ????J Clin Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=33560344 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33560344 #FOAvip English Wikipedia <ref>{{Cite pmid|33560344}}</ref> Association of Metformin with Susceptibility to COVID-19 in People with Type 2 Diabetes #MMPMID33560344 Wang J; Cooper JM; Gokhale K; Acosta-Mena D; Dhalla S; Byne N; Chandan JS; Anand A; Okoth K; Subramanian A; Bangash MN; Jackson T; Zemedikun D; Taverner T; Hanif W; Ghosh S; Narendran P; Toulis KA; Tahrani AA; Surenthirakumaran R; Adderley NJ; Haroon S; Khunti K; Sainsbury C; Thomas GN; Nirantharakumar K J Clin Endocrinol Metab 2021[Apr]; 106 (5): 1255-1268 PMID33560344show ga OBJECTIVE: Diabetes has emerged as an important risk factor for mortality from COVID-19. Metformin, the most commonly prescribed glucose-lowering agent, has been proposed to influence susceptibility to and outcomes of COVID-19 via multiple mechanisms. We investigated whether, in patients with diabetes, metformin is associated with susceptibility to COVID-19 and its outcomes. RESEARCH DESIGN AND METHODS: We performed a propensity score-matched cohort study with active comparators using a large UK primary care dataset. Adults with type 2 diabetes patients and a current prescription for metformin and other glucose-lowering agents (MF+) were compared to those with a current prescription for glucose-lowering agents that did not include metformin (MF-). Outcomes were confirmed COVID-19, suspected/confirmed COVID-19, and associated mortality. A negative control outcome analysis (back pain) was also performed. RESULTS: There were 29 558 and 10 271 patients in the MF+ and MF- groups, respectively, who met the inclusion criteria. In the propensity score-matched analysis, the adjusted hazard ratios for suspected/confirmed COVID-19, confirmed COVID-19, and COVID-19-related mortality were 0.85 (95% CI 0.67, 1.08), 0.80 (95% CI 0.49, 1.30), and 0.87 (95% CI 0.34, 2.20) respectively. The negative outcome control analysis did not suggest unobserved confounding. CONCLUSION: Current prescription of metformin was not associated with the risk of COVID-19 or COVID-19-related mortality. It is safe to continue prescribing metformin to improve glycemic control in patients with. |Aged[MESH] |COVID-19/complications/*epidemiology[MESH] |Cohort Studies[MESH] |Diabetes Mellitus, Type 2/complications/drug therapy/*epidemiology[MESH] |Female[MESH] |Humans[MESH] |Hypoglycemic Agents/*administration & dosage[MESH] |Kaplan-Meier Estimate[MESH] |Male[MESH] |Metformin/*administration & dosage[MESH] |Middle Aged[MESH] |Propensity Score[MESH]Association of Metformin with Susceptibility to COVID-19 in People wit(epmc).pdf DeepDyve Pubget Overpricing