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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Nat+Med 2021 ; 27 (4): 620-621 Nephropedia Template TP
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Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera #MMPMID33558724
Xie X; Liu Y; Liu J; Zhang X; Zou J; Fontes-Garfias CR; Xia H; Swanson KA; Cutler M; Cooper D; Menachery VD; Weaver SC; Dormitzer PR; Shi PY
Nat Med 2021[Apr]; 27 (4): 620-621 PMID33558724show ga
We engineered three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses containing key spike mutations from the newly emerged United Kingdom (UK) and South African (SA) variants: N501Y from UK and SA; 69/70-deletion + N501Y + D614G from UK; and E484K + N501Y + D614G from SA. Neutralization geometric mean titers (GMTs) of 20 BTN162b2 vaccine-elicited human sera against the three mutant viruses were 0.81- to 1.46-fold of the GMTs against parental virus, indicating small effects of these mutations on neutralization by sera elicited by two BNT162b2 doses.