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10.1038/s41591-021-01270-4

http://scihub22266oqcxt.onion/10.1038/s41591-021-01270-4
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33558724!ä!33558724

suck abstract from ncbi


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pmid33558724      Nat+Med 2021 ; 27 (4): 620-621
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  • Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera #MMPMID33558724
  • Xie X; Liu Y; Liu J; Zhang X; Zou J; Fontes-Garfias CR; Xia H; Swanson KA; Cutler M; Cooper D; Menachery VD; Weaver SC; Dormitzer PR; Shi PY
  • Nat Med 2021[Apr]; 27 (4): 620-621 PMID33558724show ga
  • We engineered three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses containing key spike mutations from the newly emerged United Kingdom (UK) and South African (SA) variants: N501Y from UK and SA; 69/70-deletion + N501Y + D614G from UK; and E484K + N501Y + D614G from SA. Neutralization geometric mean titers (GMTs) of 20 BTN162b2 vaccine-elicited human sera against the three mutant viruses were 0.81- to 1.46-fold of the GMTs against parental virus, indicating small effects of these mutations on neutralization by sera elicited by two BNT162b2 doses.
  • |*Mutation[MESH]
  • |*Neutralization Tests[MESH]
  • |BNT162 Vaccine[MESH]
  • |COVID-19 Vaccines/*immunology[MESH]
  • |Humans[MESH]
  • |SARS-CoV-2/*immunology[MESH]
  • |Spike Glycoprotein, Coronavirus/*genetics/immunology[MESH]


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