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T Cell Phenotyping in Individuals Hospitalized with COVID-19 #MMPMID33558375
J Immunol 2021[Apr]; 206 (7): 1478-1482 PMID33558375show ga
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has become pandemic. Cytokine release syndrome occurring in a minority of SARS-CoV-2 infections is associated with severe disease and high mortality. We profiled the composition, activation, and proliferation of T cells in 20 patients with severe or critical COVID-19 and 40 matched healthy controls by flow cytometry. Unsupervised hierarchical cluster analysis based on 18 T cell subsets resulted in separation of healthy controls and COVID-19 patients. Compared to healthy controls, patients suffering from severe and critical COVID-19 had increased frequencies of activated and proliferating CD38(+)Ki67(+) CD4(+) and CD8(+) T cells, suggesting active antiviral T cell defense. Frequencies of CD38(+)Ki67(+) Th1 and CD4(+) cells correlated negatively with plasma IL-6. Thus, our data suggest that patients suffering from COVID-19 have a distinct T cell composition that is potentially modulated by IL-6.
J+Immunol 2021 ; 206 (7): 1478-1482
