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10.1186/s13054-020-03433-0 http://scihub22266oqcxt.onion/10.1186/s13054-020-03433-0 33557868!7868865!33557868     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Crit+Care 2021 ; 25 (1): 52 Nephropedia Template TP {{tp|p=33557868|t=2021. Static compliance of the respiratory system in COVID-19 related ARDS: an international multicenter study |pdf=|usr=}}{{33557868}} gab.com Text Static compliance of the respiratory system in COVID-19 related ARDS: an international multicenter study JO: Crit Care http://www.kidney.de/pget.php?&tw=1&pmid=33557868 #FOAvip BACKGROUND: Controversies exist on the nature of COVID-19 related acute respiratory distress syndrome (ARDS) in particular on the static compliance of the respiratory system (Crs). We aimed to analyze the association of Crs with outcome in COVID-19-associated ARDS, to ascertain its determinants and to describe its evolution at day-14. METHODS: In this observational multicenter cohort of patients with moderate to severe Covid-19 ARDS, Crs was measured at day-1 and day-14. Association between Crs or Crs/ideal body weight (IBW) and breathing without assistance at day-28 was analyzed with multivariable logistic regression. Determinants were ascertained by multivariable linear regression. Day-14 Crs was compared to day-1 Crs with paired t-test in patients still under controlled mechanical ventilation. RESULTS: The mean Crs in 372 patients was 37.6 +/- 13 mL/cmH(2)O, similar to as in ARDS of other causes. Multivariate linear regression identified chronic hypertension, low PaO(2)/FiO(2) ratio, low PEEP, and low tidal volume as associated with lower Crs/IBW. After adjustment on confounders, nor Crs [OR 1.0 (CI 95% 0.98-1.02)] neither Crs/IBW [OR 0.63 (CI 95% 0.13-3.1)] were associated with the chance of breathing without assistance at day-28 whereas plateau pressure was [OR 0.93 (CI 95% 0.88-0.99)]. In a subset of 108 patients, day-14 Crs decreased compared to day-1 Crs (31.2 +/- 14.4 mL/cmH(2)O vs 37.8 +/- 11.4 mL/cmH(2)O, p < 0.001). The decrease in Crs was not associated with day-28 outcome. CONCLUSION: In a large multicenter cohort of moderate to severe COVID-19 ARDS, mean Crs was decreased below 40 mL/cmH(2)O and was not associated with day-28 outcome. Crs decreased between day-1 and day-14 but the decrease was not associated with day-28 outcome. Twit Text FOAVip Static compliance of the respiratory system in COVID-19 related ARDS: an international multicenter study ????Crit Care http://www.kidney.de/pget.php?&tw=1&pmid=33557868 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33557868 #FOAvip English Wikipedia <ref>{{Cite pmid|33557868}}</ref> Static compliance of the respiratory system in COVID-19 related ARDS: an international multicenter study #MMPMID33557868 Vandenbunder B; Ehrmann S; Piagnerelli M; Sauneuf B; Serck N; Soumagne T; Textoris J; Vinsonneau C; Aissaoui N; Blonz G; Carbutti G; Courcelle R; D'hondt A; Gaudry S; Higny J; Horlait G; Hraiech S; Lefebvre L; Lejeune F; Ly A; Lascarrou JB; Grimaldi D Crit Care 2021[Feb]; 25 (1): 52 PMID33557868show ga BACKGROUND: Controversies exist on the nature of COVID-19 related acute respiratory distress syndrome (ARDS) in particular on the static compliance of the respiratory system (Crs). We aimed to analyze the association of Crs with outcome in COVID-19-associated ARDS, to ascertain its determinants and to describe its evolution at day-14. METHODS: In this observational multicenter cohort of patients with moderate to severe Covid-19 ARDS, Crs was measured at day-1 and day-14. Association between Crs or Crs/ideal body weight (IBW) and breathing without assistance at day-28 was analyzed with multivariable logistic regression. Determinants were ascertained by multivariable linear regression. Day-14 Crs was compared to day-1 Crs with paired t-test in patients still under controlled mechanical ventilation. RESULTS: The mean Crs in 372 patients was 37.6 +/- 13 mL/cmH(2)O, similar to as in ARDS of other causes. Multivariate linear regression identified chronic hypertension, low PaO(2)/FiO(2) ratio, low PEEP, and low tidal volume as associated with lower Crs/IBW. After adjustment on confounders, nor Crs [OR 1.0 (CI 95% 0.98-1.02)] neither Crs/IBW [OR 0.63 (CI 95% 0.13-3.1)] were associated with the chance of breathing without assistance at day-28 whereas plateau pressure was [OR 0.93 (CI 95% 0.88-0.99)]. In a subset of 108 patients, day-14 Crs decreased compared to day-1 Crs (31.2 +/- 14.4 mL/cmH(2)O vs 37.8 +/- 11.4 mL/cmH(2)O, p < 0.001). The decrease in Crs was not associated with day-28 outcome. CONCLUSION: In a large multicenter cohort of moderate to severe COVID-19 ARDS, mean Crs was decreased below 40 mL/cmH(2)O and was not associated with day-28 outcome. Crs decreased between day-1 and day-14 but the decrease was not associated with day-28 outcome. |Aged[MESH] |COVID-19/*complications/*physiopathology/*therapy[MESH] |Cohort Studies[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Respiratory Distress Syndrome/*etiology/*physiopathology/*therapy[MESH]Static compliance of the respiratory system in COVID-19 related ARDS: (epmc).pdf DeepDyve Pubget Overpricing