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10.1186/s12879-021-05847-9

http://scihub22266oqcxt.onion/10.1186/s12879-021-05847-9
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33557779!7868864!33557779
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suck abstract from ncbi


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pmid33557779      BMC+Infect+Dis 2021 ; 21 (1): 156
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  • Differences of blood cells, lymphocyte subsets and cytokines in COVID-19 patients with different clinical stages: a network meta-analysis #MMPMID33557779
  • Yan W; Chen D; Bigambo FM; Wei H; Wang X; Xia Y
  • BMC Infect Dis 2021[Feb]; 21 (1): 156 PMID33557779show ga
  • BACKGROUND: Due to the rapid spread of coronavirus disease 2019 (COVID-19) worldwide, it is necessary to ascertain essential immune inflammatory parameters that describe the severity of the disease and provide guidance for treatment. We performed network meta-analyses to determine differences in blood cells, lymphocyte subsets, and cytokines in COVID-19 patients with different clinical stages. METHODS: Databases were systematically searched to May 2, 2020, and updated on June 1, 2020. Network meta-analyses were conducted via Stata 15.0, and the mean difference (MD) and its 95% CI were used as the effect values of the pooled analysis. RESULTS: Seventy-one studies were included involving 8647 COVID-19 patients, White blood cell (WBC), neutrophil (NEUT), IL-6, and IL-10 counts increased significantly with worsening of the COVID-19, while lymphocyte (LYM) counts decreased. The levels of platelet (PLT), CD3(+), CD4(+), CD8(+), and CD19(+) cells in severe and critical patients were significantly lower than those in mild patients. IL-1beta count was significantly elevated in critical patients. CONCLUSIONS: Immune suppression and inflammatory injury play crucial roles in the progression of COVID-19, and the identification of susceptible cells and cytokines provide guidance for the early and accurate treatment of COVID-19 patients.
  • |*Blood Cells[MESH]
  • |*Lymphocyte Subsets[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |COVID-19/*blood/*immunology[MESH]
  • |Cytokines/*blood[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Inflammation[MESH]
  • |Interleukin-10/blood[MESH]
  • |Interleukin-1beta/blood[MESH]
  • |Lymphocyte Count[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Network Meta-Analysis[MESH]
  • |Neutrophils[MESH]


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