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10.3390/biom11020216 http://scihub22266oqcxt.onion/10.3390/biom11020216 33557097!7913859!33557097     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomolecules 2021 ; 11 (2): ä Nephropedia Template TP {{tp|p=33557097|t=2021. In Silico Screening of Natural Products Isolated from Mexican Herbal Medicines against COVID-19 |pdf=|usr=}}{{33557097}} gab.com Text In Silico Screening of Natural Products Isolated from Mexican Herbal Medicines against COVID-19 JO: Biomolecules http://www.kidney.de/pget.php?&tw=1&pmid=33557097 #FOAvip The COVID-19 pandemic has already taken the lives of more than 2 million people worldwide, causing several political and socio-economic disturbances in our daily life. At the time of publication, there are non-effective pharmacological treatments, and vaccine distribution represents an important challenge for all countries. In this sense, research for novel molecules becomes essential to develop treatments against the SARS-CoV-2 virus. In this context, Mexican natural products have proven to be quite useful for drug development; therefore, in the present study, we perform an in silico screening of 100 compounds isolated from the most commonly used Mexican plants, against the SARS-CoV-2 virus. As results, we identify ten compounds that meet leadlikeness criteria (emodin anthrone, kaempferol, quercetin, aesculin, cichoriin, luteolin, matricin, riolozatrione, monocaffeoyl tartaric acid, aucubin). According to the docking analysis, only three compounds target the key proteins of SARS-CoV-2 (quercetin, riolozatrione and cichoriin), but only one appears to be safe (cichoriin). ADME (absorption, distribution, metabolism and excretion) properties and the physiologically based pharmacokinetic (PBPK) model show that cichoriin reaches higher lung levels (100 mg/Kg, IV); therefore, it may be considered in developing therapeutic tools. Twit Text FOAVip In Silico Screening of Natural Products Isolated from Mexican Herbal Medicines against COVID-19 ????Biomolecules http://www.kidney.de/pget.php?&tw=1&pmid=33557097 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33557097 #FOAvip English Wikipedia <ref>{{Cite pmid|33557097}}</ref> In Silico Screening of Natural Products Isolated from Mexican Herbal Medicines against COVID-19 #MMPMID33557097 Rivero-Segura NA; Gomez-Verjan JC Biomolecules 2021[Feb]; 11 (2): ä PMID33557097show ga The COVID-19 pandemic has already taken the lives of more than 2 million people worldwide, causing several political and socio-economic disturbances in our daily life. At the time of publication, there are non-effective pharmacological treatments, and vaccine distribution represents an important challenge for all countries. In this sense, research for novel molecules becomes essential to develop treatments against the SARS-CoV-2 virus. In this context, Mexican natural products have proven to be quite useful for drug development; therefore, in the present study, we perform an in silico screening of 100 compounds isolated from the most commonly used Mexican plants, against the SARS-CoV-2 virus. As results, we identify ten compounds that meet leadlikeness criteria (emodin anthrone, kaempferol, quercetin, aesculin, cichoriin, luteolin, matricin, riolozatrione, monocaffeoyl tartaric acid, aucubin). According to the docking analysis, only three compounds target the key proteins of SARS-CoV-2 (quercetin, riolozatrione and cichoriin), but only one appears to be safe (cichoriin). ADME (absorption, distribution, metabolism and excretion) properties and the physiologically based pharmacokinetic (PBPK) model show that cichoriin reaches higher lung levels (100 mg/Kg, IV); therefore, it may be considered in developing therapeutic tools. |*COVID-19 Drug Treatment[MESH] |*Computer Simulation[MESH] |*Drug Evaluation, Preclinical[MESH] |*Herbal Medicine[MESH] |*Medicine, Traditional[MESH] |Biological Products/*analysis/chemistry/pharmacology/*therapeutic use[MESH] |COVID-19/*virology[MESH] |Cheminformatics[MESH] |Humans[MESH] |Molecular Docking Simulation[MESH]In Silico Screening of Natural Products Isolated from Mexican Herbal M(epmc).pdf DeepDyve Pubget Overpricing