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10.1016/j.biopha.2021.111313

http://scihub22266oqcxt.onion/10.1016/j.biopha.2021.111313
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33556871!7857046!33556871
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suck abstract from ncbi


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pmid33556871      Biomed+Pharmacother 2021 ; 137 (ä): 111313
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  • An update review of emerging small-molecule therapeutic options for COVID-19 #MMPMID33556871
  • Tian D; Liu Y; Liang C; Xin L; Xie X; Zhang D; Wan M; Li H; Fu X; Liu H; Cao W
  • Biomed Pharmacother 2021[May]; 137 (ä): 111313 PMID33556871show ga
  • The SARS-CoV-2 outbreak and pandemic that began near the end of 2019 has posed a challenge to global health. At present, many candidate small-molecule therapeutics have been developed that can inhibit both the infection and replication of SARS-CoV-2 and even potentially relieve cytokine storms and other related complications. Meanwhile, host-targeted drugs that inhibit cellular transmembrane serine protease (TMPRSS2) can prevent SARS-CoV-2 from entering cells, and its combination with chloroquine and dihydroorotate dehydrogenase (DHODH) inhibitors can limit the spread of SARS-CoV-2 and reduce the morbidity and mortality of patients with COVID-19. The present article provides an overview of these small-molecule therapeutics based on insights from medicinal chemistry research and focuses on RNA-dependent RNA polymerase (RdRp) inhibitors, such as the nucleoside analogues remdesivir, favipiravir and ribavirin. This review also covers inhibitors of 3C-like protease (3CL(pro)), papain-like protease (PL(pro)) and other potentially innovative active ingredient molecules, describing their potential targets, activities, clinical status and side effects.
  • |*Antiviral Agents/classification/pharmacology[MESH]
  • |*COVID-19 Drug Treatment[MESH]
  • |*COVID-19/metabolism[MESH]
  • |*SARS-CoV-2/drug effects/enzymology[MESH]
  • |Enzyme Inhibitors/pharmacology[MESH]
  • |Humans[MESH]
  • |Molecular Targeted Therapy/*methods[MESH]


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