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10.1371/journal.pone.0246536

http://scihub22266oqcxt.onion/10.1371/journal.pone.0246536
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33556086!7870088!33556086
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suck abstract from ncbi


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pmid33556086      PLoS+One 2021 ; 16 (2): e0246536
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  • Comparison of the clinical performance and usefulness of five SARS-CoV-2 antibody tests #MMPMID33556086
  • Wakita M; Idei M; Saito K; Horiuchi Y; Yamatani K; Ishikawa S; Yamamoto T; Igawa G; Hinata M; Kadota K; Kurosawa T; Takahashi S; Saito T; Misawa S; Akazawa C; Naito T; Miida T; Takahashi K; Ai T; Tabe Y
  • PLoS One 2021[]; 16 (2): e0246536 PMID33556086show ga
  • We examined the usefulness of five COVID-19 antibody detection tests using 114 serum samples at various time points from 34 Japanese COVID-19 patients. We examined Elecsys Anti-SARS-CoV-2 from Roche, and four immunochromatography tests from Hangzhou Laihe Biotech, Artron Laboratories, Chil, and Nadal. In the first week after onset, Elecsys had 40% positivity in Group S (severe cases) but was negative in Group M (mild-moderate cases). The immunochromatography kits showed 40-60% and 0-8% positivity in Groups S and M, respectively. In the second week, Elecsys showed 75% and 50% positivity, and the immunochromatography tests showed 5-80% and 50-75% positivity in Groups S and M, respectively. After the third week, Elecsys showed 100% positivity in both groups. The immunochromatography kits showed 100% positivity in Group S. In Group M, positivity decreased to 50% for Chil and 75-89% for Artron and Lyher. Elecsys and immunochromatography kits had 91-100% specificity. Elecsys had comparable chronological change of cut-off index values in the two groups from the second week to the sixth week. The current SARS-CoV-2 antibody detection tests do not provide meaningful interpretation of severity and infection status. Its use might be limited to short-term epidemiological studies.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Antibodies, Viral/*immunology[MESH]
  • |COVID-19 Serological Testing/*methods[MESH]
  • |COVID-19/*diagnosis/*immunology/virology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Reagent Kits, Diagnostic[MESH]
  • |SARS-CoV-2/physiology[MESH]


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