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10.1371/journal.pone.0246636 http://scihub22266oqcxt.onion/10.1371/journal.pone.0246636 33556081!7870020!33556081     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2021 ; 16 (2): e0246636 Nephropedia Template TP {{tp|p=33556081|t=2021. Microvascular flow alterations in critically ill COVID-19 patients: A prospective study |pdf=|usr=}}{{33556081}} gab.com Text Microvascular flow alterations in critically ill COVID-19 patients: A prospective study JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=33556081 #FOAvip BACKGROUND: Data on microcirculatory pattern of COVID-19 critically ill patients are scarce. The objective was to compare sublingual microcirculation parameters of critically ill patients according to the severity of the disease. METHODS: The study is a single-center prospective study with critically ill COVID-19 patients admitted in ICU. Sublingual microcirculation was assessed by IDF microscopy within 48 hours of ICU admission. Microcirculatory flow index (MFI), proportion of perfused vessel (PPV), total vessel density (TVD), De Backer score (DBS), perfused vessel density (PVD) and heterogeneity index (HI) were assessed. Patients were divided in 2 groups (severe and critical) according to the World health organization definition. FINDINGS: From 19th of March to 7th of April 2020, 43 patients were included. Fourteen patients (33%) were in the severe group and twenty-nine patients (67%) in the critical group. Patients in the critical group were all mechanically ventilated. The critical group had significantly higher values of MFI, DBS and PVD in comparison to severe group (respectively, PaCO2: 49 [44-45] vs 36 [33-37] mmHg; p<0,0001, MFI: 2.8 +/- 0.2 vs 2.5 +/- 0.3; p = 0.001, DBS: 12.7 +/- 2.6 vs 10.8 +/- 2.0 vessels mm-2; p = 0.033, PVD: 12.5 +/- 3.0 vs 10.1 +/- 2.4 mm.mm-2; p = 0.020). PPV, HI and TVD were similar between groups Correlation was found between microcirculatory parameters and PaCO2 levels. CONCLUSION: Critical COVID-19 patients under mechanical ventilation seem to have higher red blood cell velocity than severe non-ventilated patients. Twit Text FOAVip Microvascular flow alterations in critically ill COVID-19 patients: A prospective study ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=33556081 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33556081 #FOAvip English Wikipedia <ref>{{Cite pmid|33556081}}</ref> Microvascular flow alterations in critically ill COVID-19 patients: A prospective study #MMPMID33556081 Abou-Arab O; Beyls C; Khalipha A; Guilbart M; Huette P; Malaquin S; Lecat B; Macq PY; Roger PA; Haye G; Bernasinski M; Besserve P; Soriot-Thomas S; Jounieaux V; Dupont H; Mahjoub Y PLoS One 2021[]; 16 (2): e0246636 PMID33556081show ga BACKGROUND: Data on microcirculatory pattern of COVID-19 critically ill patients are scarce. The objective was to compare sublingual microcirculation parameters of critically ill patients according to the severity of the disease. METHODS: The study is a single-center prospective study with critically ill COVID-19 patients admitted in ICU. Sublingual microcirculation was assessed by IDF microscopy within 48 hours of ICU admission. Microcirculatory flow index (MFI), proportion of perfused vessel (PPV), total vessel density (TVD), De Backer score (DBS), perfused vessel density (PVD) and heterogeneity index (HI) were assessed. Patients were divided in 2 groups (severe and critical) according to the World health organization definition. FINDINGS: From 19th of March to 7th of April 2020, 43 patients were included. Fourteen patients (33%) were in the severe group and twenty-nine patients (67%) in the critical group. Patients in the critical group were all mechanically ventilated. The critical group had significantly higher values of MFI, DBS and PVD in comparison to severe group (respectively, PaCO2: 49 [44-45] vs 36 [33-37] mmHg; p<0,0001, MFI: 2.8 +/- 0.2 vs 2.5 +/- 0.3; p = 0.001, DBS: 12.7 +/- 2.6 vs 10.8 +/- 2.0 vessels mm-2; p = 0.033, PVD: 12.5 +/- 3.0 vs 10.1 +/- 2.4 mm.mm-2; p = 0.020). PPV, HI and TVD were similar between groups Correlation was found between microcirculatory parameters and PaCO2 levels. CONCLUSION: Critical COVID-19 patients under mechanical ventilation seem to have higher red blood cell velocity than severe non-ventilated patients. |*Critical Illness[MESH] |Aged[MESH] |COVID-19/*physiopathology/virology[MESH] |Carbon Dioxide/metabolism[MESH] |Female[MESH] |Hemodynamics[MESH] |Humans[MESH] |Intensive Care Units[MESH] |Male[MESH] |Microcirculation/*physiology[MESH] |Microvessels/*physiopathology[MESH] |Middle Aged[MESH] |Oxygen/metabolism[MESH] |Partial Pressure[MESH] |Prospective Studies[MESH]Microvascular flow alterations in critically ill COVID-19 patients: A (epmc).pdf DeepDyve Pubget Overpricing