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10.1080/22221751.2021.1887767 http://scihub22266oqcxt.onion/10.1080/22221751.2021.1887767 33555988!7928010!33555988     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Emerg+Microbes+Infect 2021 ; 10 (1): 342-355 Nephropedia Template TP {{tp|p=33555988|t=2021. A novel DNA and protein combination COVID-19 vaccine formulation provides full protection against SARS-CoV-2 in rhesus macaques |pdf=|usr=}}{{33555988}} gab.com Text A novel DNA and protein combination COVID-19 vaccine formulation provides full protection against SARS-CoV-2 in rhesus macaques JO: Emerg Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=33555988 #FOAvip The current study aims to develop a safe and highly immunogenic COVID-19 vaccine. The novel combination of a DNA vaccine encoding the full-length Spike (S) protein of SARS-CoV-2 and a recombinant S1 protein vaccine induced high level neutralizing antibody and T cell immune responses in both small and large animal models. More significantly, the co-delivery of DNA and protein components at the same time elicited full protection against intratracheal challenge of SARS-CoV-2 viruses in immunized rhesus macaques. As both DNA and protein vaccines have been proven safe in previous human studies, and DNA vaccines are capable of eliciting germinal center B cell development, which is critical for high-affinity memory B cell responses, the DNA and protein co-delivery vaccine approach has great potential to serve as a safe and effective approach to develop COVID-19 vaccines that provide long-term protection. Twit Text FOAVip A novel DNA and protein combination COVID-19 vaccine formulation provides full protection against SARS-CoV-2 in rhesus macaques ????Emerg Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=33555988 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33555988 #FOAvip English Wikipedia <ref>{{Cite pmid|33555988}}</ref> A novel DNA and protein combination COVID-19 vaccine formulation provides full protection against SARS-CoV-2 in rhesus macaques #MMPMID33555988 Li Y; Bi Y; Xiao H; Yao Y; Liu X; Hu Z; Duan J; Yang Y; Li Z; Li Y; Zhang H; Ding C; Yang J; Li H; He Z; Liu L; Hu G; Liu S; Che Y; Wang S; Li Q; Lu S; Cun W Emerg Microbes Infect 2021[Dec]; 10 (1): 342-355 PMID33555988show ga The current study aims to develop a safe and highly immunogenic COVID-19 vaccine. The novel combination of a DNA vaccine encoding the full-length Spike (S) protein of SARS-CoV-2 and a recombinant S1 protein vaccine induced high level neutralizing antibody and T cell immune responses in both small and large animal models. More significantly, the co-delivery of DNA and protein components at the same time elicited full protection against intratracheal challenge of SARS-CoV-2 viruses in immunized rhesus macaques. As both DNA and protein vaccines have been proven safe in previous human studies, and DNA vaccines are capable of eliciting germinal center B cell development, which is critical for high-affinity memory B cell responses, the DNA and protein co-delivery vaccine approach has great potential to serve as a safe and effective approach to develop COVID-19 vaccines that provide long-term protection. |Animals[MESH] |Antibodies, Neutralizing/blood/immunology[MESH] |Antibodies, Viral/blood/immunology[MESH] |COVID-19 Vaccines/*immunology[MESH] |COVID-19/*prevention & control[MESH] |Cell Line[MESH] |DNA/immunology[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Lymphocyte Count[MESH] |Macaca mulatta[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Plasmids/genetics[MESH] |Rabbits[MESH] |Recombinant Proteins/immunology[MESH] |SARS-CoV-2/genetics/immunology[MESH] |Spike Glycoprotein, Coronavirus/*immunology[MESH] |T-Lymphocytes/immunology[MESH] |Vaccines, DNA/*immunology[MESH]A novel DNA and protein combination COVID-19 vaccine formulation provi(epmc).pdf DeepDyve Pubget Overpricing