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10.1016/j.eprac.2020.10.014 http://scihub22266oqcxt.onion/10.1016/j.eprac.2020.10.014 33554871!7837186!33554871     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Endocr+Pract 2021 ; 27 (2): 83-89 Nephropedia Template TP {{tp|p=33554871|t=2021. The Impact of COVID-19 Viral Infection on the Hypothalamic-Pituitary-Adrenal Axis |pdf=|usr=}}{{33554871}} gab.com Text The Impact of COVID-19 Viral Infection on the Hypothalamic-Pituitary-Adrenal Axis JO: Endocr Pract http://www.kidney.de/pget.php?&tw=1&pmid=33554871 #FOAvip OBJECTIVE: To study the adrenocortical response to an acute coronavirus disease-2019 (COVID-19) infection. METHODS: Morning plasma cortisol, adrenocorticotropic hormone (ACTH), and dehydroepiandrosterone sulfate levels were measured in 28 consecutive patients with COVID-19 (16 men, 12 women, median age 45.5 years, range 25-69 years) on day 1 to 2 of hospital admission. These tests were repeated twice in 20 patients and thrice in 15 patients on different days. The hormone levels were correlated with severity of the disease. RESULTS: The median morning cortisol level was 196 (31-587) nmol/L. It was <100 nmol/L in 8 patients (28.6%), <200 nmol/L in 14 patients (50%), and <300 nmol/L in 18 patients (64.3%). The corresponding ACTH values had a median of 18.5 ng/L (range 4-38 ng/L), and the ACTH level was <10 ng/L in 7 patients (26.9%), <20 ng/L in 17 patients (60.7%), and <30 ng/L in 23 patients (82.1%). The repeated testing on different days showed a similar pattern. Overall, if a cutoff level of <300 nmol/L is considered abnormal in the setting of acute disease, 9 patients (32%) had cortisol levels below this limit, regardless of whether the test was done only once (3 patients) or 3 times (6 patients). When the disease was more severe, the patients had lower cortisol and ACTH levels, suggesting a direct link between the COVID-19 infection and impaired glucocorticoid response. CONCLUSION: Unexpectedly, the adrenocortical response in patients with COVID-19 infection was impaired, and a significant percentage of the patients had plasma cortisol and ACTH levels consistent with central adrenal insufficiency. Twit Text FOAVip The Impact of COVID-19 Viral Infection on the Hypothalamic-Pituitary-Adrenal Axis ????Endocr Pract http://www.kidney.de/pget.php?&tw=1&pmid=33554871 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33554871 #FOAvip English Wikipedia <ref>{{Cite pmid|33554871}}</ref> The Impact of COVID-19 Viral Infection on the Hypothalamic-Pituitary-Adrenal Axis #MMPMID33554871 Alzahrani AS; Mukhtar N; Aljomaiah A; Aljamei H; Bakhsh A; Alsudani N; Elsayed T; Alrashidi N; Fadel R; Alqahtani E; Raef H; Butt MI; Sulaiman O Endocr Pract 2021[Feb]; 27 (2): 83-89 PMID33554871show ga OBJECTIVE: To study the adrenocortical response to an acute coronavirus disease-2019 (COVID-19) infection. METHODS: Morning plasma cortisol, adrenocorticotropic hormone (ACTH), and dehydroepiandrosterone sulfate levels were measured in 28 consecutive patients with COVID-19 (16 men, 12 women, median age 45.5 years, range 25-69 years) on day 1 to 2 of hospital admission. These tests were repeated twice in 20 patients and thrice in 15 patients on different days. The hormone levels were correlated with severity of the disease. RESULTS: The median morning cortisol level was 196 (31-587) nmol/L. It was <100 nmol/L in 8 patients (28.6%), <200 nmol/L in 14 patients (50%), and <300 nmol/L in 18 patients (64.3%). The corresponding ACTH values had a median of 18.5 ng/L (range 4-38 ng/L), and the ACTH level was <10 ng/L in 7 patients (26.9%), <20 ng/L in 17 patients (60.7%), and <30 ng/L in 23 patients (82.1%). The repeated testing on different days showed a similar pattern. Overall, if a cutoff level of <300 nmol/L is considered abnormal in the setting of acute disease, 9 patients (32%) had cortisol levels below this limit, regardless of whether the test was done only once (3 patients) or 3 times (6 patients). When the disease was more severe, the patients had lower cortisol and ACTH levels, suggesting a direct link between the COVID-19 infection and impaired glucocorticoid response. CONCLUSION: Unexpectedly, the adrenocortical response in patients with COVID-19 infection was impaired, and a significant percentage of the patients had plasma cortisol and ACTH levels consistent with central adrenal insufficiency. |*COVID-19[MESH] |*Hypothalamo-Hypophyseal System[MESH] |Adrenocorticotropic Hormone[MESH] |Adult[MESH] |Aged[MESH] |Female[MESH] |Humans[MESH] |Hydrocortisone[MESH] |Male[MESH] |Middle Aged[MESH] |Pituitary-Adrenal System[MESH]The Impact of COVID-19 Viral Infection on the Hypothalamic-Pituitary-A(epmc).pdf DeepDyve Pubget Overpricing