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10.1016/j.medj.2021.01.005 http://scihub22266oqcxt.onion/10.1016/j.medj.2021.01.005 33554155!7847406!33554155     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33554155&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Med 2021 ; 2 (3): 313-320.e4 Nephropedia Template TP {{tp|p=33554155|t=2021. Stable neutralizing antibody levels 6 months after mild and severe COVID-19 episodes |pdf=|usr=}}{{33554155}} gab.com Text Stable neutralizing antibody levels 6 months after mild and severe COVID-19 episodes JO: Med http://www.kidney.de/pget.php?&tw=1&pmid=33554155 #FOAvip BACKGROUND: Understanding mid-term kinetics of immunity to SARS-CoV-2 is the cornerstone for public health control of the pandemic and vaccine development. However, current evidence is rather based on limited measurements, losing sight of the temporal pattern of these changes. METHODS: We conducted a longitudinal analysis on a prospective cohort of COVID-19 patients followed up for >6 months. Neutralizing activity was evaluated using HIV reporter pseudoviruses expressing SARS-CoV-2 S protein. IgG antibody titer was evaluated by ELISA against the S2 subunit, the receptor binding domain (RBD), and the nucleoprotein (NP). Statistical analyses were carried out using mixed-effects models. FINDINGS: We found that individuals with mild or asymptomatic infection experienced an insignificant decay in neutralizing activity, which persisted 6 months after symptom onset or diagnosis. Hospitalized individuals showed higher neutralizing titers, which decreased following a 2-phase pattern, with an initial rapid decline that significantly slowed after day 80. Despite this initial decay, neutralizing activity at 6 months remained higher among hospitalized individuals compared to mild symptomatic. The slow decline in neutralizing activity at mid-term contrasted with the steep slope of anti-RBD, S2, or NP antibody titers, all of them showing a constant decline over the follow-up period. CONCLUSIONS: Our results reinforce the hypothesis that the quality of the neutralizing immune response against SARS-CoV-2 evolves over the post-convalescent stage. Twit Text FOAVip Stable neutralizing antibody levels 6 months after mild and severe COVID-19 episodes ????Med http://www.kidney.de/pget.php?&tw=1&pmid=33554155 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33554155 #FOAvip English Wikipedia <ref>{{Cite pmid|33554155}}</ref> Stable neutralizing antibody levels 6 months after mild and severe COVID-19 episodes #MMPMID33554155 Pradenas E; Trinite B; Urrea V; Marfil S; Avila-Nieto C; Rodriguez de la Concepcion ML; Tarres-Freixas F; Perez-Yanes S; Rovirosa C; Ainsua-Enrich E; Rodon J; Vergara-Alert J; Segales J; Guallar V; Valencia A; Izquierdo-Useros N; Paredes R; Mateu L; Chamorro A; Massanella M; Carrillo J; Clotet B; Blanco J Med 2021[Mar]; 2 (3): 313-320.e4 PMID33554155show ga BACKGROUND: Understanding mid-term kinetics of immunity to SARS-CoV-2 is the cornerstone for public health control of the pandemic and vaccine development. However, current evidence is rather based on limited measurements, losing sight of the temporal pattern of these changes. METHODS: We conducted a longitudinal analysis on a prospective cohort of COVID-19 patients followed up for >6 months. Neutralizing activity was evaluated using HIV reporter pseudoviruses expressing SARS-CoV-2 S protein. IgG antibody titer was evaluated by ELISA against the S2 subunit, the receptor binding domain (RBD), and the nucleoprotein (NP). Statistical analyses were carried out using mixed-effects models. FINDINGS: We found that individuals with mild or asymptomatic infection experienced an insignificant decay in neutralizing activity, which persisted 6 months after symptom onset or diagnosis. Hospitalized individuals showed higher neutralizing titers, which decreased following a 2-phase pattern, with an initial rapid decline that significantly slowed after day 80. Despite this initial decay, neutralizing activity at 6 months remained higher among hospitalized individuals compared to mild symptomatic. The slow decline in neutralizing activity at mid-term contrasted with the steep slope of anti-RBD, S2, or NP antibody titers, all of them showing a constant decline over the follow-up period. CONCLUSIONS: Our results reinforce the hypothesis that the quality of the neutralizing immune response against SARS-CoV-2 evolves over the post-convalescent stage. |*Antibodies, Neutralizing[MESH] |*COVID-19[MESH] |Antibodies, Viral[MESH] |Humans[MESH] |Prospective Studies[MESH] |SARS-CoV-2[MESH]Stable neutralizing antibody levels 6 months after mild and severe COV(epmc).pdf DeepDyve Pubget Overpricing