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10.1016/j.imu.2021.100529 http://scihub22266oqcxt.onion/10.1016/j.imu.2021.100529 33553571!7847290!33553571     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33553571&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Inform+Med+Unlocked 2021 ; 23 (ä): 100529 Nephropedia Template TP {{tp|p=33553571|t=2021. The screening and evaluation of potential clinically significant HIV drug combinations against the SARS-CoV-2 virus |pdf=|usr=}}{{33553571}} gab.com Text The screening and evaluation of potential clinically significant HIV drug combinations against the SARS-CoV-2 virus JO: Inform Med Unlocked http://www.kidney.de/pget.php?&tw=1&pmid=33553571 #FOAvip Spike glycoprotein is essential for the reproduction of the SARS-CoV-2 virus, and its inhibition using already approved antiviral drugs may open new avenues for treatment of patients with the COVID-19 disease. Because of that we analyzed the inhibition of SARS-CoV-2 spike glycoprotein with FDA-approved antiviral drugs and their double and triple combinations. We used the VINI in silico model of cancer to perform this virtual drug screening, showing HIV drugs to be the most effective. Besides, the combination of cobicistat-abacavir-rilpivirine HIV drugs demonstrated the highest in silico efficacy of inhibiting SARS-CoV-2 spike glycoprotein. Therefore, a clinical trial of cobicistat-abacavir-rilpivirine on a limited number of COVID-19 patients in moderately severe and severe condition is warranted. Twit Text FOAVip The screening and evaluation of potential clinically significant HIV drug combinations against the SARS-CoV-2 virus ????Inform Med Unlocked http://www.kidney.de/pget.php?&tw=1&pmid=33553571 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33553571 #FOAvip English Wikipedia <ref>{{Cite pmid|33553571}}</ref> The screening and evaluation of potential clinically significant HIV drug combinations against the SARS-CoV-2 virus #MMPMID33553571 Tomic D; Davidovic D; Szasz AM; Rezeli M; Pirkic B; Petrik J; Vrca VB; Jandel V; Lipic T; Skala K; Mesaric J; Perisa MM; Sojat Z; Rogina BM Inform Med Unlocked 2021[]; 23 (ä): 100529 PMID33553571show ga Spike glycoprotein is essential for the reproduction of the SARS-CoV-2 virus, and its inhibition using already approved antiviral drugs may open new avenues for treatment of patients with the COVID-19 disease. Because of that we analyzed the inhibition of SARS-CoV-2 spike glycoprotein with FDA-approved antiviral drugs and their double and triple combinations. We used the VINI in silico model of cancer to perform this virtual drug screening, showing HIV drugs to be the most effective. Besides, the combination of cobicistat-abacavir-rilpivirine HIV drugs demonstrated the highest in silico efficacy of inhibiting SARS-CoV-2 spike glycoprotein. Therefore, a clinical trial of cobicistat-abacavir-rilpivirine on a limited number of COVID-19 patients in moderately severe and severe condition is warranted. äThe screening and evaluation of potential clinically significant HIV d(epmc).pdf DeepDyve Pubget Overpricing