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10.2174/0929867328666210125113938 http://scihub22266oqcxt.onion/10.2174/0929867328666210125113938 33550959!ä!33550959 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Med+Chem 2021 ; 28 (27): 5498-5526 Nephropedia Template TP {{tp|p=33550959|t=2021. Natural Products as Potential Agents against SARS-CoV and SARSCoV- 2 |pdf=|usr=}}{{33550959}} gab.com Text Natural Products as Potential Agents against SARS-CoV and SARSCoV- 2 JO: Curr Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=33550959 #FOAvip BACKGROUND: Natural products are useful agents for the discovery of new lead- compounds and effective drugs to combat coronaviruses (CoV). OBJECTIVE: The present work provides an overview of natural substances, plant extracts, and essential oils as potential anti-SARS-CoV agents. In addition, this work evaluates their drug-like properties which are essential in the selection of compounds in order to accelerate the drug development process. METHODS: The search was carried out using PubMed, ScienceDirect and SciFinder. Articles addressing plant-based natural products as potential SARS-CoV or SARS-CoV-2 agents within the last seventeen years were analyzed and selected. The descriptors for Chemometrics analysis were obtained in alvaDesc and the principal component analysis (PCA) was carried out in SIMCA version 13.0. RESULTS: Based on in vitro assays and computational analyses, this review covers twentynine medicinal plant species and more than 300 isolated substances as potential anti-coronavirus agents. Among them, flavonoids and terpenes are the most promising compound classes. In silico analyses of drug-like properties corroborate these findings and indicate promising candidates for in vitro and in vivo studies to validate their activity. CONCLUSION: This paper highlights the role of ethnopharmacology in drug discovery and suggests the use of integrative (in silico/ in vitro) and chemocentric approaches to strengthen current studies and guide future research in the field of antiviral agents. Twit Text FOAVip Natural Products as Potential Agents against SARS-CoV and SARSCoV- 2 ????Curr Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=33550959 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33550959 #FOAvip English Wikipedia <ref>{{Cite pmid|33550959}}</ref> Natural Products as Potential Agents against SARS-CoV and SARSCoV- 2 #MMPMID33550959 Raimundo E Silva JP; Acevedo CAH; de Souza TA; de Menezes RPB; Sessions ZL; Abreu LS; Cibulski SP; Scotti L; da Silva MS; Muratov EN; Scotti MT; Tavares JF Curr Med Chem 2021[]; 28 (27): 5498-5526 PMID33550959show ga BACKGROUND: Natural products are useful agents for the discovery of new lead- compounds and effective drugs to combat coronaviruses (CoV). OBJECTIVE: The present work provides an overview of natural substances, plant extracts, and essential oils as potential anti-SARS-CoV agents. In addition, this work evaluates their drug-like properties which are essential in the selection of compounds in order to accelerate the drug development process. METHODS: The search was carried out using PubMed, ScienceDirect and SciFinder. Articles addressing plant-based natural products as potential SARS-CoV or SARS-CoV-2 agents within the last seventeen years were analyzed and selected. The descriptors for Chemometrics analysis were obtained in alvaDesc and the principal component analysis (PCA) was carried out in SIMCA version 13.0. RESULTS: Based on in vitro assays and computational analyses, this review covers twentynine medicinal plant species and more than 300 isolated substances as potential anti-coronavirus agents. Among them, flavonoids and terpenes are the most promising compound classes. In silico analyses of drug-like properties corroborate these findings and indicate promising candidates for in vitro and in vivo studies to validate their activity. CONCLUSION: This paper highlights the role of ethnopharmacology in drug discovery and suggests the use of integrative (in silico/ in vitro) and chemocentric approaches to strengthen current studies and guide future research in the field of antiviral agents. |*Biological Products/pharmacology[MESH] |*COVID-19[MESH] |*Plants, Medicinal[MESH] |Antiviral Agents/pharmacology/therapeutic use[MESH] |Humans[MESH]Natural Products as Potential Agents against SARS-CoV and SARSCoV- 2 (epmc).pdf DeepDyve Pubget Overpricing