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10.19723/j.issn.1671-167X.2021.01.024 http://scihub22266oqcxt.onion/10.19723/j.issn.1671-167X.2021.01.024 33550351!7867986!33550351     free     free     free Warning: Undefined variable $yww in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 538 Warning: Undefined variable $yww in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 538       Beijing+Da+Xue+Xue+Bao+Yi+Xue+Ban 2020 ; 53 (1): 159-166 Nephropedia Template TP {{tp|p=33550351|t=2020. Hypoxia and inflammation are risk factors for acute myocardial injury in patients with coronavirus disease 2019 |pdf=|usr=}}{{33550351}} gab.com Text Hypoxia and inflammation are risk factors for acute myocardial injury in patients with coronavirus disease 2019 JO: Beijing Da Xue Xue Bao Yi Xue Ban http://www.kidney.de/pget.php?&tw=1&pmid=33550351 #FOAvip OBJECTIVE: To investigate the risk factors for acute myocardial injury in coronavirus disease 2019 (COVID-19) patients. METHODS: This is a retrospective analysis of a COVID-19 cohort, in which 149 confirmed COVID-19 patients enrolled were divided into the group of myocardial injury (19 cases) and the group of non-myocardial injury (130 cases). Myocardial injury was defined according to Fourth universal definition of myocardial infarction released by European Society of Cardiology (ESC) in 2018, that cardiac troponin (cTn) was above 99th percentile of the reference level. Clinical information and results of laboratory tests of the eligible patients were collected. Factors associated with myocardial injury in COVID-19 patients were evaluated. RESULTS: Compared with the group of non-injury, the patients in the group of injury were older and had a larger proportion of severe or critical cases (P < 0.05), higher respiratory rate and lower percutaneous oxygen saturation (SpO(2)) without oxygen therapy on admission (P < 0.05). All inflammatory indexes except for tumor necrosis factor alpha (TNF-alpha) showed significant elevation in the patients of the group of injury (P < 0.05). Analyzed by Spearman correlation test, we showed that the levels of circulatory cTnI were in positive correlation with the levels of high-sensitivity C-reactive protein (hs-CRP), ferritin, receptor of interleukin-2 (IL-2R), interleukin-6 (IL-6) and interleukin-8 (IL-8) (rho > 0, P < 0.05). Lower SpO(2) without oxygen therapy on admission (OR: 0.860, 95%CI: 0.779-0.949, P=0.003) and higher plasma IL-6 levels (OR: 1.068, 95%CI: 1.019-1.120, P=0.006) were independent risk factors for acute myocardial injury in the patients with COVID-19 by multivariate Logistic regression analyses. CONCLUSION: Hypoxic state and inflammation may play a key role in the pathogenesis of acute myocardial injury in COVID-19 patients. Twit Text FOAVip Hypoxia and inflammation are risk factors for acute myocardial injury in patients with coronavirus disease 2019 ????Beijing Da Xue Xue Bao Yi Xue Ban http://www.kidney.de/pget.php?&tw=1&pmid=33550351 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33550351 #FOAvip English Wikipedia <ref>{{Cite pmid|33550351}}</ref> Hypoxia and inflammation are risk factors for acute myocardial injury in patients with coronavirus disease 2019 #MMPMID33550351 Yang LC; Zhang RT; Guo LJ; Xiao H; Zu LY; Zhang YY; Cheng Q; Zhao ZL; Ge QG; Gao W Beijing Da Xue Xue Bao Yi Xue Ban 2020[Dec]; 53 (1): 159-166 PMID33550351show ga OBJECTIVE: To investigate the risk factors for acute myocardial injury in coronavirus disease 2019 (COVID-19) patients. METHODS: This is a retrospective analysis of a COVID-19 cohort, in which 149 confirmed COVID-19 patients enrolled were divided into the group of myocardial injury (19 cases) and the group of non-myocardial injury (130 cases). Myocardial injury was defined according to Fourth universal definition of myocardial infarction released by European Society of Cardiology (ESC) in 2018, that cardiac troponin (cTn) was above 99th percentile of the reference level. Clinical information and results of laboratory tests of the eligible patients were collected. Factors associated with myocardial injury in COVID-19 patients were evaluated. RESULTS: Compared with the group of non-injury, the patients in the group of injury were older and had a larger proportion of severe or critical cases (P < 0.05), higher respiratory rate and lower percutaneous oxygen saturation (SpO(2)) without oxygen therapy on admission (P < 0.05). All inflammatory indexes except for tumor necrosis factor alpha (TNF-alpha) showed significant elevation in the patients of the group of injury (P < 0.05). Analyzed by Spearman correlation test, we showed that the levels of circulatory cTnI were in positive correlation with the levels of high-sensitivity C-reactive protein (hs-CRP), ferritin, receptor of interleukin-2 (IL-2R), interleukin-6 (IL-6) and interleukin-8 (IL-8) (rho > 0, P < 0.05). Lower SpO(2) without oxygen therapy on admission (OR: 0.860, 95%CI: 0.779-0.949, P=0.003) and higher plasma IL-6 levels (OR: 1.068, 95%CI: 1.019-1.120, P=0.006) were independent risk factors for acute myocardial injury in the patients with COVID-19 by multivariate Logistic regression analyses. CONCLUSION: Hypoxic state and inflammation may play a key role in the pathogenesis of acute myocardial injury in COVID-19 patients. |*COVID-19[MESH] |Biomarkers[MESH] |Humans[MESH] |Hypoxia[MESH] |Inflammation[MESH] |Retrospective Studies[MESH] |Risk Factors[MESH] Hypoxia and inflammation are risk factors for acute myocardial injury(epmc).pdf DeepDyve Pubget Overpricing