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10.1016/j.ejmech.2021.113233 http://scihub22266oqcxt.onion/10.1016/j.ejmech.2021.113233 33550179!7995807!33550179     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Med+Chem 2021 ; 214 (ä): 113233 Nephropedia Template TP {{tp|p=33550179|t=2021. Advance of structural modification of nucleosides scaffold |pdf=|usr=}}{{33550179}} gab.com Text Advance of structural modification of nucleosides scaffold JO: Eur J Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=33550179 #FOAvip With Remdesivir being approved by FDA as a drug for the treatment of Corona Virus Disease 2019 (COVID-19), nucleoside drugs have once again received widespread attention in the medical community. Herein, we summarized modification of traditional nucleoside framework (sugar + base), traizole nucleosides, nucleoside analogues assembled by other drugs, macromolecule-modified nucleosides, and their bioactivity rules. 2'-"Ara"-substituted by -F or -CN group, and 3'-"ara" substituted by acetylenyl group can greatly influence their anti-tumor activities. Dideoxy dehydrogenation of 2',3'-sites can enhance antiviral efficiencies. Acyclic nucleosides and L-type nucleosides mainly represented antiviral capabilities. 5-F Substituted uracil analogues exihibit anti-tumor effects, and the substrates substituted by -I, -CF(3), bromovinyl group usually show antiviral activities. The sugar coupled with 1-N of triazolid usually displays anti-tumor efficiencies, while the sugar coupled with 2-N of triazolid mainly represents antiviral activities. The nucleoside analogues assembled by cholesterol, polyethylene glycol, fatty acid and phospholipid would improve their bioavailabilities and bioactivities, or reduce their toxicities. Twit Text FOAVip Advance of structural modification of nucleosides scaffold ????Eur J Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=33550179 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33550179 #FOAvip English Wikipedia <ref>{{Cite pmid|33550179}}</ref> Advance of structural modification of nucleosides scaffold #MMPMID33550179 Lin X; Liang C; Zou L; Yin Y; Wang J; Chen D; Lan W Eur J Med Chem 2021[Mar]; 214 (ä): 113233 PMID33550179show ga With Remdesivir being approved by FDA as a drug for the treatment of Corona Virus Disease 2019 (COVID-19), nucleoside drugs have once again received widespread attention in the medical community. Herein, we summarized modification of traditional nucleoside framework (sugar + base), traizole nucleosides, nucleoside analogues assembled by other drugs, macromolecule-modified nucleosides, and their bioactivity rules. 2'-"Ara"-substituted by -F or -CN group, and 3'-"ara" substituted by acetylenyl group can greatly influence their anti-tumor activities. Dideoxy dehydrogenation of 2',3'-sites can enhance antiviral efficiencies. Acyclic nucleosides and L-type nucleosides mainly represented antiviral capabilities. 5-F Substituted uracil analogues exihibit anti-tumor effects, and the substrates substituted by -I, -CF(3), bromovinyl group usually show antiviral activities. The sugar coupled with 1-N of triazolid usually displays anti-tumor efficiencies, while the sugar coupled with 2-N of triazolid mainly represents antiviral activities. The nucleoside analogues assembled by cholesterol, polyethylene glycol, fatty acid and phospholipid would improve their bioavailabilities and bioactivities, or reduce their toxicities. |Antineoplastic Agents/*chemistry[MESH] |Antiviral Agents/*chemistry[MESH]Advance of structural modification of nucleosides scaffold (epmc).pdf DeepDyve Pubget Overpricing