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10.1016/j.medcli.2020.11.010

http://scihub22266oqcxt.onion/10.1016/j.medcli.2020.11.010
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suck abstract from ncbi


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pmid33549331      Med+Clin+(Barc) 2021 ; 156 (7): 332-335
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  • Relacion entre los niveles de interleucina 6 y depresion en pacientes afectados por Covid-19 #MMPMID33549331
  • Serrano Garcia A; Montanchez Mateo J; Franch Pato CM; Gomez Martinez R; Garcia Vazquez P; Gonzalez Rodriguez I
  • Med Clin (Barc) 2021[Apr]; 156 (7): 332-335 PMID33549331show ga
  • INTRODUCTION: Rise of central cytokines resulting from infections produces neuronal changes. Covid-19 allows the study of depressive symptoms in sustained stress and its relationship with molecular mechanisms. OBJECTIVES: To assess correlation between IL-6, IL-1beta and TNF-alpha and depressive symptoms. Characterize the depressive symptoms present. METHODS: Observational study. Patients admitted for Covid-19 older than 60 years with a interleukin determination were included. The Yesavage Geriatric Depression Scale (GDS) was used, associating each item with a neurotransmitter. RESULTS: 27 patients included. We did not find correlation between IL-6 levels and the GDS scale score (rho=0.204; 95% CI -0.192 to 0.543); with IL-1beta levels (rho=-0.126; 95% CI -0.490 to 0.276); nor of TNF-alpha (rho=-0.033; 95% CI -0.416 to 0.360). 3 patients (11.1%) presented score compatible with depressive disorder. It was associated with a deficiency of noradrenaline and serotonin. CONCLUSIONS: We found no correlation between the levels of IL-6, IL-1beta, and TNF-alpha with the GDS score. Depressive symptomatology is similar to vascular depressions.
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Biomarkers/blood[MESH]
  • |COVID-19/blood/immunology/*psychology[MESH]
  • |Depression/blood/diagnosis/*immunology/*virology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Interleukin-1beta/*blood[MESH]
  • |Interleukin-6/*blood[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Psychiatric Status Rating Scales[MESH]
  • |Risk Factors[MESH]


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