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10.1016/j.micpath.2021.104779 http://scihub22266oqcxt.onion/10.1016/j.micpath.2021.104779 33548481!7857983!33548481     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Microb+Pathog 2021 ; 153 (ä): 104779 Nephropedia Template TP {{tp|p=33548481|t=2021. Pronounce expression of Tim-3 and CD39 but not PD1 defines CD8 T cells in critical Covid-19 patients |pdf=|usr=}}{{33548481}} gab.com Text Pronounce expression of Tim-3 and CD39 but not PD1 defines CD8 T cells in critical Covid-19 patients JO: Microb Pathog http://www.kidney.de/pget.php?&tw=1&pmid=33548481 #FOAvip BACKGROUND: During viral infection, inhibitory receptors play a key role in regulating CD8 T-cell activity. The objective of this research was to investigate programmed cell death protein 1 (PD-1), T-cell immunoglobulin and mucin domain-containing protein-3 (TIM-3), and CD39 exhaustion markers in CD8 T cells of new coronavirus disease-2019 (COVID-19) patients. METHODS: A total of 44 patients with COVID-19 (17 subjects in a critical group and 27 patients in a non-critical group) and 14 healthy controls, who were admitted to Hospitals in Babol, were recruited to the study. In subjects' peripheral blood mononuclear cells (PBMCs), we compared the phenotype of CD8 T lymphocytes, expressing PD-1, TIM-3, or CD39, both alone and in various combinations. RESULTS: The findings showed that the percentage of CD8(+) cells was significantly lower in patients. Critical and non-critical patients were more likely than healthy controls to have an escalated frequency of CD8(+) TIM-3(+), CD8(+) CD39(+), and CD8(+) TIM-3(+) CD39(+) cells. No significant differences were observed between all groups in the CD8(+) PD-1(+) cell counts. There was also no difference between three groups regarding the counts of CD8(+) TIM-3(+) PD-1(+), CD8(+) PD-1(+) CD39(+), and CD8(+) TIM-3(+) PD-1(+) CD39(+) cells. The counts of non-exhausted cells were significantly lower in critical and non-critical individuals compared to the healthy individuals' value. CONCLUSION: Patients, infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), altered exhausted CD8 T lymphocytes with CD39 and TIM-3 exhaustion markers, which may account the dysregulated immune response found in COVID-19. Twit Text FOAVip Pronounce expression of Tim-3 and CD39 but not PD1 defines CD8 T cells in critical Covid-19 patients ????Microb Pathog http://www.kidney.de/pget.php?&tw=1&pmid=33548481 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33548481 #FOAvip English Wikipedia <ref>{{Cite pmid|33548481}}</ref> Pronounce expression of Tim-3 and CD39 but not PD1 defines CD8 T cells in critical Covid-19 patients #MMPMID33548481 Shahbazi M; Moulana Z; Sepidarkish M; Bagherzadeh M; Rezanejad M; Mirzakhani M; Jafari M; Mohammadnia-Afrouzi M Microb Pathog 2021[Apr]; 153 (ä): 104779 PMID33548481show ga BACKGROUND: During viral infection, inhibitory receptors play a key role in regulating CD8 T-cell activity. The objective of this research was to investigate programmed cell death protein 1 (PD-1), T-cell immunoglobulin and mucin domain-containing protein-3 (TIM-3), and CD39 exhaustion markers in CD8 T cells of new coronavirus disease-2019 (COVID-19) patients. METHODS: A total of 44 patients with COVID-19 (17 subjects in a critical group and 27 patients in a non-critical group) and 14 healthy controls, who were admitted to Hospitals in Babol, were recruited to the study. In subjects' peripheral blood mononuclear cells (PBMCs), we compared the phenotype of CD8 T lymphocytes, expressing PD-1, TIM-3, or CD39, both alone and in various combinations. RESULTS: The findings showed that the percentage of CD8(+) cells was significantly lower in patients. Critical and non-critical patients were more likely than healthy controls to have an escalated frequency of CD8(+) TIM-3(+), CD8(+) CD39(+), and CD8(+) TIM-3(+) CD39(+) cells. No significant differences were observed between all groups in the CD8(+) PD-1(+) cell counts. There was also no difference between three groups regarding the counts of CD8(+) TIM-3(+) PD-1(+), CD8(+) PD-1(+) CD39(+), and CD8(+) TIM-3(+) PD-1(+) CD39(+) cells. The counts of non-exhausted cells were significantly lower in critical and non-critical individuals compared to the healthy individuals' value. CONCLUSION: Patients, infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), altered exhausted CD8 T lymphocytes with CD39 and TIM-3 exhaustion markers, which may account the dysregulated immune response found in COVID-19. |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Apyrase/*biosynthesis[MESH] |Biomarkers/analysis[MESH] |CD8-Positive T-Lymphocytes/*immunology[MESH] |COVID-19/*pathology[MESH] |Female[MESH] |Hepatitis A Virus Cellular Receptor 2/*biosynthesis[MESH] |Humans[MESH] |Iran[MESH] |Lymphocyte Count[MESH] |Male[MESH] |Middle Aged[MESH] |Programmed Cell Death 1 Receptor/*biosynthesis[MESH] |SARS-CoV-2/immunology[MESH]Pronounce expression of Tim-3 and CD39 but not PD1 defines CD8 T cells(epmc).pdf DeepDyve Pubget Overpricing