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10.1016/j.chom.2021.01.015 http://scihub22266oqcxt.onion/10.1016/j.chom.2021.01.015 33548198!7846228!33548198     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Host+Microbe 2021 ; 29 (3): 489-502.e8 Nephropedia Template TP {{tp|p=33548198|t=2021. Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon response |pdf=|usr=}}{{33548198}} gab.com Text Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon response JO: Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=33548198 #FOAvip The SARS-CoV-2 virus, the causative agent of COVID-19, is undergoing constant mutation. Here, we utilized an integrative approach combining epidemiology, virus genome sequencing, clinical phenotyping, and experimental validation to locate mutations of clinical importance. We identified 35 recurrent variants, some of which are associated with clinical phenotypes related to severity. One variant, containing a deletion in the Nsp1-coding region (Delta500-532), was found in more than 20% of our sequenced samples and associates with higher RT-PCR cycle thresholds and lower serum IFN-beta levels of infected patients. Deletion variants in this locus were found in 37 countries worldwide, and viruses isolated from clinical samples or engineered by reverse genetics with related deletions in Nsp1 also induce lower IFN-beta responses in infected Calu-3 cells. Taken together, our virologic surveillance characterizes recurrent genetic diversity and identified mutations in Nsp1 of biological and clinical importance, which collectively may aid molecular diagnostics and drug design. Twit Text FOAVip Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon response ????Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=33548198 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33548198 #FOAvip English Wikipedia <ref>{{Cite pmid|33548198}}</ref> Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon response #MMPMID33548198 Lin JW; Tang C; Wei HC; Du B; Chen C; Wang M; Zhou Y; Yu MX; Cheng L; Kuivanen S; Ogando NS; Levanov L; Zhao Y; Li CL; Zhou R; Li Z; Zhang Y; Sun K; Wang C; Chen L; Xiao X; Zheng X; Chen SS; Zhou Z; Yang R; Zhang D; Xu M; Song J; Wang D; Li Y; Lei S; Zeng W; Yang Q; He P; Zhang Y; Zhou L; Cao L; Luo F; Liu H; Wang L; Ye F; Zhang M; Li M; Fan W; Li X; Li K; Ke B; Xu J; Yang H; He S; Pan M; Yan Y; Zha Y; Jiang L; Yu C; Liu Y; Xu Z; Li Q; Jiang Y; Sun J; Hong W; Wei H; Lu G; Vapalahti O; Luo Y; Wei Y; Connor T; Tan W; Snijder EJ; Smura T; Li W; Geng J; Ying B; Chen L Cell Host Microbe 2021[Mar]; 29 (3): 489-502.e8 PMID33548198show ga The SARS-CoV-2 virus, the causative agent of COVID-19, is undergoing constant mutation. Here, we utilized an integrative approach combining epidemiology, virus genome sequencing, clinical phenotyping, and experimental validation to locate mutations of clinical importance. We identified 35 recurrent variants, some of which are associated with clinical phenotypes related to severity. One variant, containing a deletion in the Nsp1-coding region (Delta500-532), was found in more than 20% of our sequenced samples and associates with higher RT-PCR cycle thresholds and lower serum IFN-beta levels of infected patients. Deletion variants in this locus were found in 37 countries worldwide, and viruses isolated from clinical samples or engineered by reverse genetics with related deletions in Nsp1 also induce lower IFN-beta responses in infected Calu-3 cells. Taken together, our virologic surveillance characterizes recurrent genetic diversity and identified mutations in Nsp1 of biological and clinical importance, which collectively may aid molecular diagnostics and drug design. |A549 Cells[MESH] |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Animals[MESH] |Base Sequence[MESH] |COVID-19/blood/*immunology/*virology[MESH] |Cell Line[MESH] |Child[MESH] |Child, Preschool[MESH] |Chlorocebus aethiops[MESH] |Female[MESH] |Gene Deletion[MESH] |Genomics[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Infant[MESH] |Interferon Type I/blood/*immunology[MESH] |Interferon-beta/blood/metabolism[MESH] |Male[MESH] |Middle Aged[MESH] |Molecular Epidemiology[MESH] |Reverse Genetics[MESH] |SARS-CoV-2/*genetics/*immunology[MESH] |Vero Cells[MESH] |Viral Nonstructural Proteins/*genetics/immunology[MESH]Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant tha(epmc).pdf DeepDyve Pubget Overpricing