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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cytometry+A 2021 ; 99 (5): 466-471 Nephropedia Template TP
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Monocyte CD169 expression in COVID-19 patients upon intensive care unit admission #MMPMID33547747
Ortillon M; Coudereau R; Cour M; Rimmele T; Godignon M; Gossez M; Yonis H; Argaud L; Lukaszewicz AC; Venet F; Monneret G
Cytometry A 2021[May]; 99 (5): 466-471 PMID33547747show ga
During the second surge of COVID-19 in France (fall 2020), we assessed the expression of monocyte CD169 (i.e., Siglec-1, one of the numerous IFN-stimulated genes) upon admission to intensive care units of 45 patients with RT-PCR-confirmed SARS-CoV2 pulmonary infection. Overall, CD169 expression was strongly induced on circulating monocytes of COVID-19 patients compared with healthy donors and patients with bacterial sepsis. Beyond its contribution at the emergency department, CD169 testing may be also helpful for patients' triage at the ICU to rapidly reinforce suspicion of COVID-19 etiology in patients with acute respiratory failure awaiting for PCR results for definitive diagnosis.