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10.1038/s41598-021-82043-4

http://scihub22266oqcxt.onion/10.1038/s41598-021-82043-4
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33547380!7864945!33547380
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suck abstract from ncbi


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pmid33547380      Sci+Rep 2021 ; 11 (1): 3209
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  • PACIFIC: a lightweight deep-learning classifier of SARS-CoV-2 and co-infecting RNA viruses #MMPMID33547380
  • Acera Mateos P; Balboa RF; Easteal S; Eyras E; Patel HR
  • Sci Rep 2021[Feb]; 11 (1): 3209 PMID33547380show ga
  • Viral co-infections occur in COVID-19 patients, potentially impacting disease progression and severity. However, there is currently no dedicated method to identify viral co-infections in patient RNA-seq data. We developed PACIFIC, a deep-learning algorithm that accurately detects SARS-CoV-2 and other common RNA respiratory viruses from RNA-seq data. Using in silico data, PACIFIC recovers the presence and relative concentrations of viruses with > 99% precision and recall. PACIFIC accurately detects SARS-CoV-2 and other viral infections in 63 independent in vitro cell culture and patient datasets. PACIFIC is an end-to-end tool that enables the systematic monitoring of viral infections in the current global pandemic.
  • |*Deep Learning[MESH]
  • |COVID-19 Testing[MESH]
  • |COVID-19/*diagnosis[MESH]
  • |Coinfection/*diagnosis/virology[MESH]
  • |Coronaviridae/isolation & purification[MESH]
  • |Humans[MESH]
  • |Metapneumovirus/classification/isolation & purification[MESH]
  • |Neural Networks, Computer[MESH]
  • |Orthomyxoviridae/classification/isolation & purification[MESH]
  • |RNA Virus Infections/*diagnosis/virology[MESH]
  • |RNA Viruses/classification/*isolation & purification[MESH]
  • |RNA-Seq[MESH]
  • |Rhinovirus/classification/isolation & purification[MESH]
  • |SARS-CoV-2/classification/*isolation & purification[MESH]


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