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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Nat+Commun 2021 ; 12 (1): 837 Nephropedia Template TP
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Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2 #MMPMID33547281
Wrobel AG; Benton DJ; Xu P; Calder LJ; Borg A; Roustan C; Martin SR; Rosenthal PB; Skehel JJ; Gamblin SJ
Nat Commun 2021[Feb]; 12 (1): 837 PMID33547281show ga
Coronaviruses of bats and pangolins have been implicated in the origin and evolution of the pandemic SARS-CoV-2. We show that spikes from Guangdong Pangolin-CoVs, closely related to SARS-CoV-2, bind strongly to human and pangolin ACE2 receptors. We also report the cryo-EM structure of a Pangolin-CoV spike protein and show it adopts a fully-closed conformation and that, aside from the Receptor-Binding Domain, it resembles the spike of a bat coronavirus RaTG13 more than that of SARS-CoV-2.