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10.1126/sciadv.abe7386 http://scihub22266oqcxt.onion/10.1126/sciadv.abe7386 33547084!7864571!33547084     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Adv 2021 ; 7 (6): ä Nephropedia Template TP {{tp|p=33547084|t=2021. Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression |pdf=|usr=}}{{33547084}} gab.com Text Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression JO: Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=33547084 #FOAvip The ongoing unprecedented severe acute respiratory syndrome caused by the SARS-CoV-2 outbreak worldwide has highlighted the need for understanding viral-host interactions involved in mechanisms of virulence. Here, we show that the virulence factor Nsp1 protein of SARS-CoV-2 interacts with the host messenger RNA (mRNA) export receptor heterodimer NXF1-NXT1, which is responsible for nuclear export of cellular mRNAs. Nsp1 prevents proper binding of NXF1 to mRNA export adaptors and NXF1 docking at the nuclear pore complex. As a result, a significant number of cellular mRNAs are retained in the nucleus during infection. Increased levels of NXF1 rescues the Nsp1-mediated mRNA export block and inhibits SARS-CoV-2 infection. Thus, antagonizing the Nsp1 inhibitory function on mRNA export may represent a strategy to restoring proper antiviral host gene expression in infected cells. Twit Text FOAVip Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression ????Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=33547084 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33547084 #FOAvip English Wikipedia <ref>{{Cite pmid|33547084}}</ref> Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression #MMPMID33547084 Zhang K; Miorin L; Makio T; Dehghan I; Gao S; Xie Y; Zhong H; Esparza M; Kehrer T; Kumar A; Hobman TC; Ptak C; Gao B; Minna JD; Chen Z; Garcia-Sastre A; Ren Y; Wozniak RW; Fontoura BMA Sci Adv 2021[Feb]; 7 (6): ä PMID33547084show ga The ongoing unprecedented severe acute respiratory syndrome caused by the SARS-CoV-2 outbreak worldwide has highlighted the need for understanding viral-host interactions involved in mechanisms of virulence. Here, we show that the virulence factor Nsp1 protein of SARS-CoV-2 interacts with the host messenger RNA (mRNA) export receptor heterodimer NXF1-NXT1, which is responsible for nuclear export of cellular mRNAs. Nsp1 prevents proper binding of NXF1 to mRNA export adaptors and NXF1 docking at the nuclear pore complex. As a result, a significant number of cellular mRNAs are retained in the nucleus during infection. Increased levels of NXF1 rescues the Nsp1-mediated mRNA export block and inhibits SARS-CoV-2 infection. Thus, antagonizing the Nsp1 inhibitory function on mRNA export may represent a strategy to restoring proper antiviral host gene expression in infected cells. |*Gene Expression[MESH] |Active Transport, Cell Nucleus/genetics[MESH] |Animals[MESH] |COVID-19/*metabolism/virology[MESH] |Chlorocebus aethiops[MESH] |HEK293 Cells[MESH] |Host Microbial Interactions/*genetics[MESH] |Humans[MESH] |Nuclear Pore/metabolism[MESH] |Nucleocytoplasmic Transport Proteins/genetics/metabolism[MESH] |RNA, Messenger/genetics/*metabolism[MESH] |RNA-Binding Proteins/genetics/metabolism[MESH] |SARS-CoV-2/chemistry/*metabolism[MESH] |Transfection[MESH] |Vero Cells[MESH] |Viral Nonstructural Proteins/genetics/*metabolism[MESH]Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhib(epmc).pdf DeepDyve Pubget Overpricing