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10.1126/sciadv.abe5819 http://scihub22266oqcxt.onion/10.1126/sciadv.abe5819 33547083!7864572!33547083     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Adv 2021 ; 7 (6): ä Nephropedia Template TP {{tp|p=33547083|t=2021. A lymph node-targeted Amphiphile vaccine induces potent cellular and humoral immunity to SARS-CoV-2 |pdf=|usr=}}{{33547083}} gab.com Text A lymph node-targeted Amphiphile vaccine induces potent cellular and humoral immunity to SARS-CoV-2 JO: Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=33547083 #FOAvip The profound consequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mandate urgent development of effective vaccines. Here, we evaluated an Amphiphile (AMP) vaccine adjuvant, AMP-CpG, composed of diacyl lipid-modified CpG, admixed with the SARS-CoV-2 Spike-2 receptor binding domain protein as a candidate vaccine (ELI-005) in mice. AMP modification efficiently delivers CpG to lymph nodes, where innate and adaptive immune responses are generated. Compared to alum, immunization with AMP-CpG induced >25-fold higher antigen-specific T cells that produced multiple T helper 1 (T(H)1) cytokines and trafficked into lung parenchyma. Antibody responses favored T(H)1 isotypes (IgG2c and IgG3) and potently neutralized Spike-2-ACE2 receptor binding, with titers 265-fold higher than natural convalescent patient COVID-19 responses; T cell and antibody responses were maintained despite 10-fold dose reduction in Spike antigen. Both cellular and humoral immune responses were preserved in aged mice. These advantages merit clinical translation to SARS-CoV-2 and other protein subunit vaccines. Twit Text FOAVip A lymph node-targeted Amphiphile vaccine induces potent cellular and humoral immunity to SARS-CoV-2 ????Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=33547083 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33547083 #FOAvip English Wikipedia <ref>{{Cite pmid|33547083}}</ref> A lymph node-targeted Amphiphile vaccine induces potent cellular and humoral immunity to SARS-CoV-2 #MMPMID33547083 Steinbuck MP; Seenappa LM; Jakubowski A; McNeil LK; Haqq CM; DeMuth PC Sci Adv 2021[Feb]; 7 (6): ä PMID33547083show ga The profound consequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mandate urgent development of effective vaccines. Here, we evaluated an Amphiphile (AMP) vaccine adjuvant, AMP-CpG, composed of diacyl lipid-modified CpG, admixed with the SARS-CoV-2 Spike-2 receptor binding domain protein as a candidate vaccine (ELI-005) in mice. AMP modification efficiently delivers CpG to lymph nodes, where innate and adaptive immune responses are generated. Compared to alum, immunization with AMP-CpG induced >25-fold higher antigen-specific T cells that produced multiple T helper 1 (T(H)1) cytokines and trafficked into lung parenchyma. Antibody responses favored T(H)1 isotypes (IgG2c and IgG3) and potently neutralized Spike-2-ACE2 receptor binding, with titers 265-fold higher than natural convalescent patient COVID-19 responses; T cell and antibody responses were maintained despite 10-fold dose reduction in Spike antigen. Both cellular and humoral immune responses were preserved in aged mice. These advantages merit clinical translation to SARS-CoV-2 and other protein subunit vaccines. |*Immunity, Cellular[MESH] |*Immunity, Humoral[MESH] |Adjuvants, Immunologic/administration & dosage[MESH] |Animals[MESH] |Antibodies, Neutralizing/immunology[MESH] |Antibodies, Viral/immunology[MESH] |COVID-19 Vaccines/*administration & dosage/immunology[MESH] |COVID-19/*prevention & control/virology[MESH] |Female[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Immunogenicity, Vaccine[MESH] |Lymph Nodes/*immunology[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Mice, Inbred C57BL[MESH] |Neutralization Tests[MESH] |Oligodeoxyribonucleotides/administration & dosage/immunology[MESH] |Protein Interaction Domains and Motifs/immunology[MESH] |SARS-CoV-2/*immunology[MESH] |Spike Glycoprotein, Coronavirus/chemistry/immunology[MESH] |Surface-Active Agents/*administration & dosage[MESH] |Treatment Outcome[MESH] |Vaccination/methods[MESH]A lymph node-targeted Amphiphile vaccine induces potent cellular and h(epmc).pdf DeepDyve Pubget Overpricing