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10.1186/s12879-021-05818-0

http://scihub22266oqcxt.onion/10.1186/s12879-021-05818-0
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33546633!7863059!33546633
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suck abstract from ncbi


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pmid33546633      BMC+Infect+Dis 2021 ; 21 (1): 147
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  • High body mass index is a significant risk factor for the progression and prognosis of imported COVID-19: a multicenter, retrospective cohort study #MMPMID33546633
  • Cai H; Yang L; Lu Y; Zhang S; Ye C; Zhang X; Yu G; Gu J; Lian J; Hao S; Hu J; Zhang Y; Jin C; Sheng J; Yang Y; Jia H
  • BMC Infect Dis 2021[Feb]; 21 (1): 147 PMID33546633show ga
  • BACKGROUND: Coronavirus disease 2019(COVID-19) has spread worldwide. The present study aimed to characterize the clinical features and outcomes of imported COVID-19 patients with high body mass index (BMI) and the independent association of BMI with disease severity. METHODS: In this retrospective cohort study, 455 imported COVID-19 patients were admitted and discharged in Zhejiang province by February 28, 2020. Epidemiological, demographic, clinical, laboratory, radiological, treatment, and outcome data were collected, analyzed and compared between patients with BMI >/= 24and < 24. RESULTS: A total of 268 patients had BMI < 24, and 187 patients had BMI >/= 24. Those with high BMI were mostly men, had a smoking history, fever, cough, and sputum than those with BMI < 24. A large number of patients with BMI >/= 24 were diagnosed as severe/critical types. Some biochemical indicators were significantly elevated in patients with BMI >/= 24. Also, acute liver injury was the most common complication in these patients. The median days from illness onset to severe acute respiratory syndrome coronavirus 2 detection, duration of hospitalization, and days from illness onset to discharge were significantly longer in patients with BMI >/= 24 than those with BMI < 24. High BMI, exposure to Wuhan, any coexisting medical condition, high temperature, C-reactive protein (CRP), and increased lactate dehydrogenase (LDH) were independent risk factors for severe/critical COVID-19. After adjusting for age, sex and above factors, BMI was still independently associated with progression to severe/critical illness (P = 0.0040). Hemoglobin, alanine aminotransferase (ALT), CRP, and serum creatinine (Scr) were independent risk factors associated with high BMI. CONCLUSIONS: Contrasted with the imported COVID-19 patients with BMI < 24, high proportion of COVID-19 patients with BMI >/= 24 in our study, especially those with elevated CRP and LDH, developed to severe type, with longer hospitalization duration and anti-virus course. Thus, high BMI is a risk factor for the progression and prognosis of imported COVID-19.
  • |*SARS-CoV-2[MESH]
  • |Adult[MESH]
  • |Body Mass Index[MESH]
  • |COVID-19/*epidemiology/etiology[MESH]
  • |China/epidemiology[MESH]
  • |Cohort Studies[MESH]
  • |Disease Progression[MESH]
  • |Female[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Prognosis[MESH]
  • |Retrospective Studies[MESH]


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