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10.3390/ijerph18041415 http://scihub22266oqcxt.onion/10.3390/ijerph18041415 33546463!7913756!33546463     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Environ+Res+Public+Health 2021 ; 18 (4): ä Nephropedia Template TP {{tp|p=33546463|t=2021. Neurological Sequelae in Patients with COVID-19: A Histopathological Perspective |pdf=|usr=}}{{33546463}} gab.com Text Neurological Sequelae in Patients with COVID-19: A Histopathological Perspective JO: Int J Environ Res Public Health http://www.kidney.de/pget.php?&tw=1&pmid=33546463 #FOAvip BACKGROUND: Neuroinvasive properties of SARS-CoV-2 have allowed the hypothesis of several pathogenic mechanisms related to acute and chronic neurological sequelae. However, neuropathological correlates have been poorly systematically investigated, being retrieved from reports of single case or limited case series still. METHODS: A PubMed search was carried out to review all publications on autopsy in subjects with "COronaVIrus Disease-19" (COVID-19). Among them, we focused on histological findings of the brain, which were compared with those from the authors' autoptic studies performed in some COVID-19 patients. RESULTS: Only seven studies reported histological evidence of brain pathology in patients deceased for COVID-19, including three with reverse transcription-quantitative polymerase chain reaction evidence of viral infection. All these studies, in line with our experience, showed vascular-related and infection-related secondary inflammatory tissue damage due to an abnormal immune response. It is still unclear, however, whether these findings are the effect of a direct viral pathology or rather reflect a non-specific consequence of cardiovascular and pulmonary disease on the brain. CONCLUSIONS: Notwithstanding the limited evidence available and the heterogeneity of the studies, we provide a preliminary description of the relationship between SARS-CoV-2 and brain sequelae. Systematic autoptic investigations are needed for accurate detection and adequate management of these patients. Twit Text FOAVip Neurological Sequelae in Patients with COVID-19: A Histopathological Perspective ????Int J Environ Res Public Health http://www.kidney.de/pget.php?&tw=1&pmid=33546463 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33546463 #FOAvip English Wikipedia <ref>{{Cite pmid|33546463}}</ref> Neurological Sequelae in Patients with COVID-19: A Histopathological Perspective #MMPMID33546463 Fisicaro F; Di Napoli M; Liberto A; Fanella M; Di Stasio F; Pennisi M; Bella R; Lanza G; Mansueto G Int J Environ Res Public Health 2021[Feb]; 18 (4): ä PMID33546463show ga BACKGROUND: Neuroinvasive properties of SARS-CoV-2 have allowed the hypothesis of several pathogenic mechanisms related to acute and chronic neurological sequelae. However, neuropathological correlates have been poorly systematically investigated, being retrieved from reports of single case or limited case series still. METHODS: A PubMed search was carried out to review all publications on autopsy in subjects with "COronaVIrus Disease-19" (COVID-19). Among them, we focused on histological findings of the brain, which were compared with those from the authors' autoptic studies performed in some COVID-19 patients. RESULTS: Only seven studies reported histological evidence of brain pathology in patients deceased for COVID-19, including three with reverse transcription-quantitative polymerase chain reaction evidence of viral infection. All these studies, in line with our experience, showed vascular-related and infection-related secondary inflammatory tissue damage due to an abnormal immune response. It is still unclear, however, whether these findings are the effect of a direct viral pathology or rather reflect a non-specific consequence of cardiovascular and pulmonary disease on the brain. CONCLUSIONS: Notwithstanding the limited evidence available and the heterogeneity of the studies, we provide a preliminary description of the relationship between SARS-CoV-2 and brain sequelae. Systematic autoptic investigations are needed for accurate detection and adequate management of these patients. |Autopsy[MESH] |Brain/*pathology[MESH] |COVID-19/*complications[MESH] |Humans[MESH]Neurological Sequelae in Patients with COVID-19: A Histopathological P(epmc).pdf DeepDyve Pubget Overpricing