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10.3390/v13020234

http://scihub22266oqcxt.onion/10.3390/v13020234
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33546185!7913267!33546185
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suck abstract from ncbi


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pmid33546185      Viruses 2021 ; 13 (2): ä
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  • Thapsigargin Is a Broad-Spectrum Inhibitor of Major Human Respiratory Viruses: Coronavirus, Respiratory Syncytial Virus and Influenza A Virus #MMPMID33546185
  • Al-Beltagi S; Preda CA; Goulding LV; James J; Pu J; Skinner P; Jiang Z; Wang BL; Yang J; Banyard AC; Mellits KH; Gershkovich P; Hayes CJ; Nguyen-Van-Tam J; Brown IH; Liu J; Chang KC
  • Viruses 2021[Feb]; 13 (2): ä PMID33546185show ga
  • The long-term control strategy of SARS-CoV-2 and other major respiratory viruses needs to include antivirals to treat acute infections, in addition to the judicious use of effective vaccines. Whilst COVID-19 vaccines are being rolled out for mass vaccination, the modest number of antivirals in use or development for any disease bears testament to the challenges of antiviral development. We recently showed that non-cytotoxic levels of thapsigargin (TG), an inhibitor of the sarcoplasmic/endoplasmic reticulum (ER) Ca(2+) ATPase pump, induces a potent host innate immune antiviral response that blocks influenza A virus replication. Here we show that TG is also highly effective in blocking the replication of respiratory syncytial virus (RSV), common cold coronavirus OC43, SARS-CoV-2 and influenza A virus in immortalized or primary human cells. TG's antiviral performance was significantly better than remdesivir and ribavirin in their respective inhibition of OC43 and RSV. Notably, TG was just as inhibitory to coronaviruses (OC43 and SARS-CoV-2) and influenza viruses (USSR H1N1 and pdm 2009 H1N1) in separate infections as in co-infections. Post-infection oral gavage of acid-stable TG protected mice against a lethal influenza virus challenge. Together with its ability to inhibit the different viruses before or during active infection, and with an antiviral duration of at least 48 h post-TG exposure, we propose that TG (or its derivatives) is a promising broad-spectrum inhibitor against SARS-CoV-2, OC43, RSV and influenza virus.
  • |Animals[MESH]
  • |Antiviral Agents/*pharmacology/therapeutic use[MESH]
  • |Betacoronavirus/*drug effects/physiology[MESH]
  • |Cell Line[MESH]
  • |Cell Line, Tumor[MESH]
  • |Cells, Cultured[MESH]
  • |Coronavirus OC43, Human/*drug effects/physiology[MESH]
  • |Endoplasmic Reticulum Stress[MESH]
  • |Humans[MESH]
  • |Influenza A Virus, H1N1 Subtype/*drug effects/physiology[MESH]
  • |Mice[MESH]
  • |Microbial Sensitivity Tests[MESH]
  • |Orthomyxoviridae Infections/drug therapy/virology[MESH]
  • |Respiratory Syncytial Virus, Human/*drug effects/physiology[MESH]
  • |Ribavirin/pharmacology[MESH]
  • |SARS-CoV-2/*drug effects/physiology[MESH]
  • |Thapsigargin/*pharmacology/therapeutic use[MESH]


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