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Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Clin+Med 2021 ; 10 (4): ä Nephropedia Template TP
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Incidence and Prognosis of Ventilator-Associated Pneumonia in Critically Ill Patients with COVID-19: A Multicenter Study #MMPMID33546093
Giacobbe DR; Battaglini D; Enrile EM; Dentone C; Vena A; Robba C; Ball L; Bartoletti M; Coloretti I; Di Bella S; Di Biagio A; Brunetti I; Mikulska M; Carannante N; De Maria A; Magnasco L; Maraolo AE; Mirabella M; Montrucchio G; Patroniti N; Taramasso L; Tiseo G; Fornaro G; Fraganza F; Monastra L; Roman-Pognuz E; Paluzzano G; Fiorentino G; Corcione A; Bussini L; Pascale R; Corcione S; Tonetti T; Rinaldi M; Falcone M; Biagioni E; Ranieri VM; Giannella M; De Rosa FG; Girardis M; Menichetti F; Viale P; Pelosi P; Bassetti M
J Clin Med 2021[Feb]; 10 (4): ä PMID33546093show ga
The primary objective of this multicenter, observational, retrospective study was to assess the incidence rate of ventilator-associated pneumonia (VAP) in coronavirus disease 2019 (COVID-19) patients in intensive care units (ICU). The secondary objective was to assess predictors of 30-day case-fatality of VAP. From 15 February to 15 May 2020, 586 COVID-19 patients were admitted to the participating ICU. Of them, 171 developed VAP (29%) and were included in the study. The incidence rate of VAP was of 18 events per 1000 ventilator days (95% confidence intervals [CI] 16-21). Deep respiratory cultures were available and positive in 77/171 patients (45%). The most frequent organisms were Pseudomonas aeruginosa (27/77, 35%) and Staphylococcus aureus (18/77, 23%). The 30-day case-fatality of VAP was 46% (78/171). In multivariable analysis, septic shock at VAP onset (odds ratio [OR] 3.30, 95% CI 1.43-7.61, p = 0.005) and acute respiratory distress syndrome at VAP onset (OR 13.21, 95% CI 3.05-57.26, p < 0.001) were associated with fatality. In conclusion, VAP is frequent in critically ill COVID-19 patients. The related high fatality is likely the sum of the unfavorable prognostic impacts of the underlying viral and the superimposed bacterial diseases.