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10.1084/jem.20202486 http://scihub22266oqcxt.onion/10.1084/jem.20202486 33544838!7871457!33544838     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Exp+Med 2021 ; 218 (4): ä Nephropedia Template TP {{tp|p=33544838|t=2021. Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine |pdf=|usr=}}{{33544838}} gab.com Text Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=33544838 #FOAvip Yellow fever virus (YFV) live attenuated vaccine can, in rare cases, cause life-threatening disease, typically in patients with no previous history of severe viral illness. Autosomal recessive (AR) complete IFNAR1 deficiency was reported in one 12-yr-old patient. Here, we studied seven other previously healthy patients aged 13 to 80 yr with unexplained life-threatening YFV vaccine-associated disease. One 13-yr-old patient had AR complete IFNAR2 deficiency. Three other patients vaccinated at the ages of 47, 57, and 64 yr had high titers of circulating auto-Abs against at least 14 of the 17 individual type I IFNs. These antibodies were recently shown to underlie at least 10% of cases of life-threatening COVID-19 pneumonia. The auto-Abs were neutralizing in vitro, blocking the protective effect of IFN-alpha2 against YFV vaccine strains. AR IFNAR1 or IFNAR2 deficiency and neutralizing auto-Abs against type I IFNs thus accounted for more than half the cases of life-threatening YFV vaccine-associated disease studied here. Previously healthy subjects could be tested for both predispositions before anti-YFV vaccination. Twit Text FOAVip Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=33544838 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33544838 #FOAvip English Wikipedia <ref>{{Cite pmid|33544838}}</ref> Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine #MMPMID33544838 Bastard P; Michailidis E; Hoffmann HH; Chbihi M; Le Voyer T; Rosain J; Philippot Q; Seeleuthner Y; Gervais A; Materna M; de Oliveira PMN; Maia MLS; Dinis Ano Bom AP; Azamor T; Araujo da Conceicao D; Goudouris E; Homma A; Slesak G; Schafer J; Pulendran B; Miller JD; Huits R; Yang R; Rosen LB; Bizien L; Lorenzo L; Chrabieh M; Erazo LV; Rozenberg F; Jeljeli MM; Beziat V; Holland SM; Cobat A; Notarangelo LD; Su HC; Ahmed R; Puel A; Zhang SY; Abel L; Seligman SJ; Zhang Q; MacDonald MR; Jouanguy E; Rice CM; Casanova JL J Exp Med 2021[Apr]; 218 (4): ä PMID33544838show ga Yellow fever virus (YFV) live attenuated vaccine can, in rare cases, cause life-threatening disease, typically in patients with no previous history of severe viral illness. Autosomal recessive (AR) complete IFNAR1 deficiency was reported in one 12-yr-old patient. Here, we studied seven other previously healthy patients aged 13 to 80 yr with unexplained life-threatening YFV vaccine-associated disease. One 13-yr-old patient had AR complete IFNAR2 deficiency. Three other patients vaccinated at the ages of 47, 57, and 64 yr had high titers of circulating auto-Abs against at least 14 of the 17 individual type I IFNs. These antibodies were recently shown to underlie at least 10% of cases of life-threatening COVID-19 pneumonia. The auto-Abs were neutralizing in vitro, blocking the protective effect of IFN-alpha2 against YFV vaccine strains. AR IFNAR1 or IFNAR2 deficiency and neutralizing auto-Abs against type I IFNs thus accounted for more than half the cases of life-threatening YFV vaccine-associated disease studied here. Previously healthy subjects could be tested for both predispositions before anti-YFV vaccination. |*Autoimmune Diseases/genetics/immunology[MESH] |*COVID-19/genetics/immunology[MESH] |*Genetic Diseases, Inborn/genetics/immunology[MESH] |*Interferon-alpha/genetics/immunology[MESH] |*Receptor, Interferon alpha-beta/deficiency/immunology[MESH] |*SARS-CoV-2/genetics/immunology[MESH] |*Yellow Fever Vaccine/adverse effects/genetics/immunology[MESH] |*Yellow fever virus/genetics/immunology[MESH] |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Antibodies, Neutralizing/*immunology[MESH] |Autoantibodies/*immunology[MESH] |Female[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH]Auto-antibodies to type I IFNs can underlie adverse reactions to yello(epmc).pdf DeepDyve Pubget Overpricing