Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi


10.15252/emmm.202013191

http://scihub22266oqcxt.onion/10.15252/emmm.202013191
suck pdf from google scholar
33544398!7995094!33544398
unlimited free pdf from europmc33544398    free
PDF from PMC    free
html from PMC    free

suck abstract from ncbi


Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
pmid33544398      EMBO+Mol+Med 2021 ; 13 (4): e13191
Nephropedia Template TP

gab.com Text

Twit Text FOAVip

Twit Text #

English Wikipedia


  • Epithelial response to IFN-gamma promotes SARS-CoV-2 infection #MMPMID33544398
  • Heuberger J; Trimpert J; Vladimirova D; Goosmann C; Lin M; Schmuck R; Mollenkopf HJ; Brinkmann V; Tacke F; Osterrieder N; Sigal M
  • EMBO Mol Med 2021[Apr]; 13 (4): e13191 PMID33544398show ga
  • SARS-CoV-2, the agent that causes COVID-19, invades epithelial cells, including those of the respiratory and gastrointestinal mucosa, using angiotensin-converting enzyme-2 (ACE2) as a receptor. Subsequent inflammation can promote rapid virus clearance, but severe cases of COVID-19 are characterized by an inefficient immune response that fails to clear the infection. Using primary epithelial organoids from human colon, we explored how the central antiviral mediator IFN-gamma, which is elevated in COVID-19, affects epithelial cell differentiation, ACE2 expression, and susceptibility to infection with SARS-CoV-2. In mouse and human colon, ACE2 is mainly expressed by surface enterocytes. Inducing enterocyte differentiation in organoid culture resulted in increased ACE2 production. IFN-gamma treatment promoted differentiation into mature KRT20(+) enterocytes expressing high levels of ACE2, increased susceptibility to SARS-CoV-2 infection, and resulted in enhanced virus production in infected cells. Similarly, infection-induced epithelial interferon signaling promoted enterocyte maturation and enhanced ACE2 expression. We here reveal a mechanism by which IFN-gamma-driven inflammatory responses induce a vulnerable epithelial state with robust replication of SARS-CoV-2, which may have an impact on disease outcome and virus transmission.
  • |*Models, Immunological[MESH]
  • |*SARS-CoV-2/genetics/immunology/pathogenicity[MESH]
  • |Angiotensin-Converting Enzyme 2/genetics/metabolism[MESH]
  • |Animals[MESH]
  • |COVID-19/*etiology/immunology/pathology[MESH]
  • |Cell Differentiation/immunology[MESH]
  • |Colon/immunology/pathology/virology[MESH]
  • |Disease Susceptibility[MESH]
  • |Enterocytes/metabolism/pathology/virology[MESH]
  • |Gene Expression[MESH]
  • |Host Microbial Interactions/immunology[MESH]
  • |Humans[MESH]
  • |Interferon-gamma/administration & dosage/*immunology[MESH]
  • |Intestinal Mucosa/immunology/pathology/virology[MESH]
  • |Mice[MESH]
  • |Organoids/immunology/pathology/virology[MESH]


  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    Linkout box