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10.1007/s11481-020-09981-0 http://scihub22266oqcxt.onion/10.1007/s11481-020-09981-0 33544324!7862527!33544324     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Neuroimmune+Pharmacol 2021 ; 16 (2): 270-288 Nephropedia Template TP {{tp|p=33544324|t=2021. A Role for Extracellular Vesicles in SARS-CoV-2 Therapeutics and Prevention |pdf=|usr=}}{{33544324}} gab.com Text A Role for Extracellular Vesicles in SARS-CoV-2 Therapeutics and Prevention JO: J Neuroimmune Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33544324 #FOAvip Extracellular vesicles (EVs) are the common designation for ectosomes, microparticles and microvesicles serving dominant roles in intercellular communication. Both viable and dying cells release EVs to the extracellular environment for transfer of cell, immune and infectious materials. Defined morphologically as lipid bi-layered structures EVs show molecular, biochemical, distribution, and entry mechanisms similar to viruses within cells and tissues. In recent years their functional capacities have been harnessed to deliver biomolecules and drugs and immunological agents to specific cells and organs of interest or disease. Interest in EVs as putative vaccines or drug delivery vehicles are substantial. The vesicles have properties of receptors nanoassembly on their surface. EVs can interact with specific immunocytes that include antigen presenting cells (dendritic cells and other mononuclear phagocytes) to elicit immune responses or affect tissue and cellular homeostasis or disease. Due to potential advantages like biocompatibility, biodegradation and efficient immune activation, EVs have gained attraction for the development of treatment or a vaccine system against the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) infection. In this review efforts to use EVs to contain SARS CoV-2 and affect the current viral pandemic are discussed. An emphasis is made on mesenchymal stem cell derived EVs' as a vaccine candidate delivery system. Twit Text FOAVip A Role for Extracellular Vesicles in SARS-CoV-2 Therapeutics and Prevention ????J Neuroimmune Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33544324 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33544324 #FOAvip English Wikipedia <ref>{{Cite pmid|33544324}}</ref> A Role for Extracellular Vesicles in SARS-CoV-2 Therapeutics and Prevention #MMPMID33544324 Machhi J; Shahjin F; Das S; Patel M; Abdelmoaty MM; Cohen JD; Singh PA; Baldi A; Bajwa N; Kumar R; Vora LK; Patel TA; Oleynikov MD; Soni D; Yeapuri P; Mukadam I; Chakraborty R; Saksena CG; Herskovitz J; Hasan M; Oupicky D; Das S; Donnelly RF; Hettie KS; Chang L; Gendelman HE; Kevadiya BD J Neuroimmune Pharmacol 2021[Jun]; 16 (2): 270-288 PMID33544324show ga Extracellular vesicles (EVs) are the common designation for ectosomes, microparticles and microvesicles serving dominant roles in intercellular communication. Both viable and dying cells release EVs to the extracellular environment for transfer of cell, immune and infectious materials. Defined morphologically as lipid bi-layered structures EVs show molecular, biochemical, distribution, and entry mechanisms similar to viruses within cells and tissues. In recent years their functional capacities have been harnessed to deliver biomolecules and drugs and immunological agents to specific cells and organs of interest or disease. Interest in EVs as putative vaccines or drug delivery vehicles are substantial. The vesicles have properties of receptors nanoassembly on their surface. EVs can interact with specific immunocytes that include antigen presenting cells (dendritic cells and other mononuclear phagocytes) to elicit immune responses or affect tissue and cellular homeostasis or disease. Due to potential advantages like biocompatibility, biodegradation and efficient immune activation, EVs have gained attraction for the development of treatment or a vaccine system against the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) infection. In this review efforts to use EVs to contain SARS CoV-2 and affect the current viral pandemic are discussed. An emphasis is made on mesenchymal stem cell derived EVs' as a vaccine candidate delivery system. |*COVID-19 Drug Treatment[MESH] |*Extracellular Vesicles/immunology/metabolism[MESH] |Animals[MESH] |Antiviral Agents/administration & dosage/metabolism[MESH] |COVID-19/immunology/metabolism[MESH] |Drug Delivery Systems/methods/*trends[MESH] |Humans[MESH] |Immunity, Cellular/drug effects/physiology[MESH] |Immunologic Factors/administration & dosage/metabolism[MESH]A Role for Extracellular Vesicles in SARS-CoV-2 Therapeutics and Preve(epmc).pdf DeepDyve Pubget Overpricing