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10.1007/s11046-021-00528-2

http://scihub22266oqcxt.onion/10.1007/s11046-021-00528-2
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33544266!7862973!33544266
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suck abstract from ncbi


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pmid33544266      Mycopathologia 2021 ; 186 (2): 289-298
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  • Coronavirus Disease (Covid-19) Associated Mucormycosis (CAM): Case Report and Systematic Review of Literature #MMPMID33544266
  • Garg D; Muthu V; Sehgal IS; Ramachandran R; Kaur H; Bhalla A; Puri GD; Chakrabarti A; Agarwal R
  • Mycopathologia 2021[May]; 186 (2): 289-298 PMID33544266show ga
  • Severe coronavirus disease (COVID-19) is currently managed with systemic glucocorticoids. Opportunistic fungal infections are of concern in such patients. While COVID-19 associated pulmonary aspergillosis is increasingly recognized, mucormycosis is rare. We describe a case of probable pulmonary mucormycosis in a 55-year-old man with diabetes, end-stage kidney disease, and COVID-19. The index case was diagnosed with pulmonary mucormycosis 21 days following admission for severe COVID-19. He received 5 g of liposomal amphotericin B and was discharged after 54 days from the hospital. We also performed a systematic review of the literature and identified seven additional cases of COVID-19 associated mucormycosis (CAM). Of the eight cases included in our review, diabetes mellitus was the most common risk factor. Three subjects had no risk factor other than glucocorticoids for COVID-19. Mucormycosis usually developed 10-14 days after hospitalization. All except the index case died. In two subjects, CAM was diagnosed postmortem. Mucormycosis is an uncommon but serious infection that complicates the course of severe COVID-19. Subjects with diabetes mellitus and multiple risk factors may be at a higher risk for developing mucormycosis. Concurrent glucocorticoid therapy probably heightens the risk of mucormycosis. A high index of suspicion and aggressive management is required to improve outcomes.
  • |*Diabetes Complications[MESH]
  • |Adenosine Monophosphate/analogs & derivatives/therapeutic use[MESH]
  • |Alanine/analogs & derivatives/therapeutic use[MESH]
  • |Antiviral Agents/therapeutic use[MESH]
  • |COVID-19/*complications/therapy[MESH]
  • |Glucocorticoids/therapeutic use[MESH]
  • |Humans[MESH]
  • |Kidney Failure, Chronic/*complications/therapy[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Mucormycosis/*complications/microbiology/therapy[MESH]
  • |Rhizopus/isolation & purification[MESH]
  • |Risk Factors[MESH]
  • |Tomography, X-Ray Computed[MESH]


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