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10.1080/21645515.2021.1872344

http://scihub22266oqcxt.onion/10.1080/21645515.2021.1872344
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suck abstract from ncbi


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pmid33544024      Hum+Vaccin+Immunother 2021 ; 17 (8): 2451-2453
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  • Anticipated reduction in COVID-19 mortality due to population-wide BCG vaccination: evidence from Germany #MMPMID33544024
  • Marin-Hernandez D; Nixon DF; Hupert N
  • Hum Vaccin Immunother 2021[Aug]; 17 (8): 2451-2453 PMID33544024show ga
  • Bacillus Calmette-Guerin (BCG) vaccine is known to have "bystander benefits" in protecting against heterologous infections; interim analysis of the "ACTIVATE" trial shows protection against respiratory infections in the elderly population. Epidemiologic studies suggest a potential benefit of BCG vaccination on COVID-19 outcomes. Differential past BCG vaccination policies between the former East and West German states provides a unique natural experiment to assess the potential effect of prior BCG vaccination on COVID-19. We estimated a 5% heterologous vaccine efficacy in the highly vaccinated former East Germany using the COVID-19 International Modeling (CoMo) Consortium model. A comparable BCG vaccination campaign undertaken prior to the pandemic in former West Germany, instituted along with known country-wide transmission reduction measures, is associated with a 37% decrease in projected mortality by mid-summer, 2020. These findings support a combined heterologous vaccine and non-pharmaceutical interventions (HVI+NPI) approach to mitigate the SARS-CoV-2 pandemic until SARS-CoV-2 specific vaccines are widely distributed.
  • |*BCG Vaccine[MESH]
  • |*COVID-19[MESH]
  • |Aged[MESH]
  • |Germany/epidemiology[MESH]
  • |Humans[MESH]
  • |SARS-CoV-2[MESH]


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