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10.1097/AOG.0000000000004275

http://scihub22266oqcxt.onion/10.1097/AOG.0000000000004275
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33543899!7884090!33543899
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suck abstract from ncbi


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pmid33543899      Obstet+Gynecol 2021 ; 137 (3): 423-429
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  • Sex, Hormones, Immune Functions, and Susceptibility to Coronavirus Disease 2019 (COVID-19)-Related Morbidity #MMPMID33543899
  • Gotluru C; Roach A; Cherry SH; Runowicz CD
  • Obstet Gynecol 2021[Mar]; 137 (3): 423-429 PMID33543899show ga
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), uses two primary receptors, type II transmembrane serine protease and angiotensin-converting enzyme-2, for priming and cellular invasion, respectively. Both proteins have been demonstrated to be present in different concentrations in females and males, which may explain a mechanism for the reported higher case-fatality rate in males. Despite the known sex difference in COVID-19 disease mortality, preliminary data suggest there are certain female populations, including pregnant and menopausal women and possibly polycystic ovarian syndrome patients who are more susceptible to COVID-19-related morbidity. This commentary analyzes the interplay between sex differences, hormones, and the immune function in each of these populations with respect to the risk and severity of COVID-19 and proposes biological rationales to explain these differences.
  • |*Genetic Predisposition to Disease[MESH]
  • |Angiotensin-Converting Enzyme 2/genetics[MESH]
  • |COVID-19/*epidemiology/*genetics[MESH]
  • |Chromosomes, Human, X[MESH]
  • |Disease Susceptibility[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Menopause/physiology[MESH]
  • |Morbidity[MESH]
  • |Polycystic Ovary Syndrome/epidemiology[MESH]
  • |Pregnancy[MESH]
  • |SARS-CoV-2/physiology[MESH]
  • |Serine Endopeptidases/genetics[MESH]


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