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10.3389/fimmu.2020.622598 http://scihub22266oqcxt.onion/10.3389/fimmu.2020.622598 33542724!7851053!33542724     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2020 ; 11 (ä): 622598 Nephropedia Template TP {{tp|p=33542724|t=2020. SP-A and SP-D: Dual Functioning Immune Molecules With Antiviral and Immunomodulatory Properties |pdf=|usr=}}{{33542724}} gab.com Text SP-A and SP-D: Dual Functioning Immune Molecules With Antiviral and Immunomodulatory Properties JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33542724 #FOAvip Surfactant proteins A (SP-A) and D (SP-D) are soluble innate immune molecules which maintain lung homeostasis through their dual roles as anti-infectious and immunomodulatory agents. SP-A and SP-D bind numerous viruses including influenza A virus, respiratory syncytial virus (RSV) and human immunodeficiency virus (HIV), enhancing their clearance from mucosal points of entry and modulating the inflammatory response. They also have diverse roles in mediating innate and adaptive cell functions and in clearing apoptotic cells, allergens and other noxious particles. Here, we review how the properties of these first line defense molecules modulate inflammatory responses, as well as host-mediated immunopathology in response to viral infections. Since SP-A and SP-D are known to offer protection from viral and other infections, if their levels are decreased in some disease states as they are in severe asthma and chronic obstructive pulmonary disease (COPD), this may confer an increased risk of viral infection and exacerbations of disease. Recombinant molecules of SP-A and SP-D could be useful in both blocking respiratory viral infection while also modulating the immune system to prevent excessive inflammatory responses seen in, for example, RSV or coronavirus disease 2019 (COVID-19). Recombinant SP-A and SP-D could have therapeutic potential in neutralizing both current and future strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus as well as modulating the inflammation-mediated pathology associated with COVID-19. A recombinant fragment of human (rfh)SP-D has recently been shown to neutralize SARS-CoV-2. Further work investigating the potential therapeutic role of SP-A and SP-D in COVID-19 and other infectious and inflammatory diseases is indicated. Twit Text FOAVip SP-A and SP-D: Dual Functioning Immune Molecules With Antiviral and Immunomodulatory Properties ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33542724 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33542724 #FOAvip English Wikipedia <ref>{{Cite pmid|33542724}}</ref> SP-A and SP-D: Dual Functioning Immune Molecules With Antiviral and Immunomodulatory Properties #MMPMID33542724 Watson A; Madsen J; Clark HW Front Immunol 2020[]; 11 (ä): 622598 PMID33542724show ga Surfactant proteins A (SP-A) and D (SP-D) are soluble innate immune molecules which maintain lung homeostasis through their dual roles as anti-infectious and immunomodulatory agents. SP-A and SP-D bind numerous viruses including influenza A virus, respiratory syncytial virus (RSV) and human immunodeficiency virus (HIV), enhancing their clearance from mucosal points of entry and modulating the inflammatory response. They also have diverse roles in mediating innate and adaptive cell functions and in clearing apoptotic cells, allergens and other noxious particles. Here, we review how the properties of these first line defense molecules modulate inflammatory responses, as well as host-mediated immunopathology in response to viral infections. Since SP-A and SP-D are known to offer protection from viral and other infections, if their levels are decreased in some disease states as they are in severe asthma and chronic obstructive pulmonary disease (COPD), this may confer an increased risk of viral infection and exacerbations of disease. Recombinant molecules of SP-A and SP-D could be useful in both blocking respiratory viral infection while also modulating the immune system to prevent excessive inflammatory responses seen in, for example, RSV or coronavirus disease 2019 (COVID-19). Recombinant SP-A and SP-D could have therapeutic potential in neutralizing both current and future strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus as well as modulating the inflammation-mediated pathology associated with COVID-19. A recombinant fragment of human (rfh)SP-D has recently been shown to neutralize SARS-CoV-2. Further work investigating the potential therapeutic role of SP-A and SP-D in COVID-19 and other infectious and inflammatory diseases is indicated. |Animals[MESH] |Antiviral Agents/immunology/*therapeutic use[MESH] |COVID-19 Drug Treatment[MESH] |Collectins/deficiency[MESH] |Humans[MESH] |Immunologic Factors/immunology/*therapeutic use[MESH] |Inflammation/drug therapy[MESH] |Pulmonary Surfactant-Associated Protein A/immunology/*physiology/therapeutic use[MESH] |Pulmonary Surfactant-Associated Protein B/immunology/*physiology/therapeutic use[MESH] |Receptors, Scavenger/immunology[MESH]SP-A and SP-D: Dual Functioning Immune Molecules With Antiviral and I(epmc).pdf DeepDyve Pubget Overpricing