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Antibodies to SARS-CoV-2 protect against re-infection during outbreaks in care homes, September and October 2020 #MMPMID33541486
Jeffery-Smith A; Iyanger N; Williams SV; Chow JY; Aiano F; Hoschler K; Lackenby A; Ellis J; Platt S; Miah S; Brown K; Amirthalingam G; Patel M; Ramsay ME; Gopal R; Charlett A; Ladhani SN; Zambon M
Euro Surveill 2021[Feb]; 26 (5): ? PMID33541486show ga
Two London care homes experienced a second COVID-19 outbreak, with 29/209 (13.9%) SARS-CoV-2 RT-PCR-positive cases (16/103 residents, 13/106 staff). In those with prior SARS-CoV-2 exposure, 1/88 (1.1%) individuals (antibody positive: 87; RT-PCR-positive: 1) became PCR-positive compared with 22/73 (30.1%) with confirmed seronegative status. After four months protection offered by prior infection against re-infection was 96.2% (95% confidence interval (CI): 72.7-99.5%) using risk ratios from comparison of proportions and 96.1% (95% CI: 78.8-99.3%) using a penalised logistic regression model.