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10.1080/15265161.2020.1854368

http://scihub22266oqcxt.onion/10.1080/15265161.2020.1854368
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33541252!ä!33541252

suck abstract from ncbi


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pmid33541252      Am+J+Bioeth 2021 ; 21 (3): 11-31
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  • Promoting Ethical Payment in Human Infection Challenge Studies #MMPMID33541252
  • Lynch HF; Darton TC; Levy J; McCormick F; Ogbogu U; Payne RO; Roth AE; Shah AJ; Smiley T; Largent EA
  • Am J Bioeth 2021[Mar]; 21 (3): 11-31 PMID33541252show ga
  • To prepare for potential human infection challenge studies (HICS) involving SARS-CoV-2, we convened a multidisciplinary working group to address ethical questions regarding whether and how much SARS-CoV-2 HICS participants should be paid. Because the goals of paying HICS participants, as well as the relevant ethical concerns, are the same as those arising for other types of clinical research, the same basic framework for ethical payment can apply. This framework divides payment into reimbursement, compensation, and incentives, focusing on fairness and promoting adequate recruitment and retention as counterweights to concerns about undue inducement. Within the basic framework, several factors are especially salient for HICS, and for SARS-CoV-2 HICS in particular, including the nature of participant confinement, anticipated discomfort, risks and uncertainty, participant motivations, and trust. These factors are reflected in a payment worksheet created to help sponsors, researchers, and ethics reviewers systematically develop and assess ethically justifiable payment amounts.
  • |*COVID-19[MESH]
  • |Ethics, Research[MESH]
  • |Humans[MESH]
  • |Motivation[MESH]
  • |Research Design[MESH]


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