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10.1016/j.ijid.2021.01.065 http://scihub22266oqcxt.onion/10.1016/j.ijid.2021.01.065 33540128!7849442!33540128     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Infect+Dis 2021 ; 104 (ä): 671-676 Nephropedia Template TP {{tp|p=33540128|t=2021. Remdesivir and systemic corticosteroids for the treatment of COVID-19: A Bayesian re-analysis |pdf=|usr=}}{{33540128}} gab.com Text Remdesivir and systemic corticosteroids for the treatment of COVID-19: A Bayesian re-analysis JO: Int J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=33540128 #FOAvip BACKGROUND: The global death toll from coronavirus disease 2019 (COVID-19) has exceeded 2 million, and treatments to decrease mortality are needed urgently. OBJECTIVES: To examine the probabilities of a clinically meaningful reduction in mortality for remdesivir and systemic corticosteroids. DESIGN, SETTING AND PARTICIPANTS: This was a probabilistic re-analysis of clinical trial data for corticosteroids and remdesivir in the treatment of hospitalized patients with COVID-19 using a Bayesian random effects meta-analytic approach. Studies were identified from existing meta-analyses performed by the World Health Organization. MAIN OUTCOMES AND MEASURES: Posterior probabilities of an absolute decrease in mortality compared with control patients, by subgroups based on oxygen requirements, were calculated for corticosteroids and remdesivir. Probabilities of >/=1%, >/=2% and >/=5% absolute decrease in mortality were quantified. RESULTS: For patients needing mechanical ventilation, the probability of >/=1% absolute decrease in mortality was 4% for remdesivir and 93% for corticosteroids. For patients needing supplemental oxygen without mechanical ventilation, the probability of >/=1% absolute decrease in mortality was 81% for remdesivir and 93% for dexamethasone. Finally, for patients who did not need oxygen support, the probability of >/=1% absolute decrease in mortality was 29% for remdesivir and 4% for dexamethasone. CONCLUSIONS AND RELEVANCE: Using a Bayesian analytic approach, remdesivir had low probability of achieving a clinically meaningful reduction in mortality, except for patients needing supplemental oxygen without mechanical ventilation. Corticosteroids were more promising for patients needing oxygen support, especially mechanical ventilation. While awaiting more definitive studies, this probabilistic interpretation of the evidence will help to guide treatment decisions for clinicians, as well as guideline and policy makers. Twit Text FOAVip Remdesivir and systemic corticosteroids for the treatment of COVID-19: A Bayesian re-analysis ????Int J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=33540128 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33540128 #FOAvip English Wikipedia <ref>{{Cite pmid|33540128}}</ref> Remdesivir and systemic corticosteroids for the treatment of COVID-19: A Bayesian re-analysis #MMPMID33540128 Lee TC; McDonald EG; Butler-Laporte G; Harrison LB; Cheng MP; Brophy JM Int J Infect Dis 2021[Mar]; 104 (ä): 671-676 PMID33540128show ga BACKGROUND: The global death toll from coronavirus disease 2019 (COVID-19) has exceeded 2 million, and treatments to decrease mortality are needed urgently. OBJECTIVES: To examine the probabilities of a clinically meaningful reduction in mortality for remdesivir and systemic corticosteroids. DESIGN, SETTING AND PARTICIPANTS: This was a probabilistic re-analysis of clinical trial data for corticosteroids and remdesivir in the treatment of hospitalized patients with COVID-19 using a Bayesian random effects meta-analytic approach. Studies were identified from existing meta-analyses performed by the World Health Organization. MAIN OUTCOMES AND MEASURES: Posterior probabilities of an absolute decrease in mortality compared with control patients, by subgroups based on oxygen requirements, were calculated for corticosteroids and remdesivir. Probabilities of >/=1%, >/=2% and >/=5% absolute decrease in mortality were quantified. RESULTS: For patients needing mechanical ventilation, the probability of >/=1% absolute decrease in mortality was 4% for remdesivir and 93% for corticosteroids. For patients needing supplemental oxygen without mechanical ventilation, the probability of >/=1% absolute decrease in mortality was 81% for remdesivir and 93% for dexamethasone. Finally, for patients who did not need oxygen support, the probability of >/=1% absolute decrease in mortality was 29% for remdesivir and 4% for dexamethasone. CONCLUSIONS AND RELEVANCE: Using a Bayesian analytic approach, remdesivir had low probability of achieving a clinically meaningful reduction in mortality, except for patients needing supplemental oxygen without mechanical ventilation. Corticosteroids were more promising for patients needing oxygen support, especially mechanical ventilation. While awaiting more definitive studies, this probabilistic interpretation of the evidence will help to guide treatment decisions for clinicians, as well as guideline and policy makers. |*Bayes Theorem[MESH] |*COVID-19 Drug Treatment[MESH] |*SARS-CoV-2[MESH] |Adenosine Monophosphate/*analogs & derivatives/therapeutic use[MESH] |Adrenal Cortex Hormones/*therapeutic use[MESH] |Alanine/*analogs & derivatives/therapeutic use[MESH] |COVID-19/mortality[MESH] |Humans[MESH] |Probability[MESH]Remdesivir and systemic corticosteroids for the treatment of COVID-19:(epmc).pdf DeepDyve Pubget Overpricing