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10.1016/j.ijpharm.2021.120329

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suck abstract from ncbi


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pmid33540028      Int+J+Pharm 2021 ; 597 (ä): 120329
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  • Self-injectable extended release formulation of Remdesivir (SelfExRem): A potential formulation alternative for COVID-19 treatment #MMPMID33540028
  • Patki M; Palekar S; Reznik S; Patel K
  • Int J Pharm 2021[Mar]; 597 (ä): 120329 PMID33540028show ga
  • There has been a growing and evolving research to find a treatment or a prevention against coronavirus 2019 (COVID-19). Though mass vaccination will certainly help in reducing number of COVID-19 patients, an effective therapeutic measure must be available too. Intravenous remdesivir (RDV) was the first drug receiving Food and Drug Administration (FDA) approval for the treatment of COVID-19. However, in a pandemic like COVID-19, it is essential that drug formulations are readily available, affordable and convenient to administer to every patient around the globe. In this study, we have developed a Self-injectable extended release subcutaneous injection of Remdesivir (SelfExRem) for the treatment of COVID-19. As opposed to intravenous injection, extended release subcutaneous injection has the benefits of reducing face-to-face contact, minimizing hospitalization, reducing dosing frequency and reducing overall health care cost. SelfExRem was developed using a biodegradable polymer, poly(lactic-co-glycolic acid) (PLGA), dissolved in a biocompatible vehicle. Six different batches were formulated using 2 different grades of low molecular weight PLGA and 3 different PLGA concentration. The force of injection of various polymeric solutions through 23-30-gauge needles were analyzed using a TA.XTplus texture analyzer. The time required for injection was evaluated both manually and by using an autoinjector. In vitro release of all the batches were carried out in 1% v/v tween 80 in phosphate buffer saline. The study indicated that SelfExRem developed with15% w/v PLGA(75:25) provided a steady release of drug for 48 h and may be a breakthrough approach for the treatment of COVID-19.
  • |*COVID-19 Drug Treatment[MESH]
  • |*COVID-19/epidemiology/prevention & control[MESH]
  • |Adenosine Monophosphate/*analogs & derivatives/pharmacology[MESH]
  • |Alanine/*analogs & derivatives/pharmacology[MESH]
  • |Antiviral Agents/pharmacology[MESH]
  • |Delayed-Action Preparations/*pharmacology[MESH]
  • |Drug Evaluation, Preclinical[MESH]
  • |Humans[MESH]
  • |Injections, Subcutaneous/methods[MESH]
  • |Prodrugs/pharmacology[MESH]


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