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10.1371/journal.ppat.1009207

http://scihub22266oqcxt.onion/10.1371/journal.ppat.1009207
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suck abstract from ncbi


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pmid33539484      PLoS+Pathog 2021 ; 17 (2): e1009207
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  • Three-dimensional chromatin in infectious disease-A role for gene regulation and pathogenicity? #MMPMID33539484
  • Davis SZ; Hollin T; Lenz T; Le Roch KG
  • PLoS Pathog 2021[Feb]; 17 (2): e1009207 PMID33539484show ga
  • The recent Coronavirus Disease 2019 pandemic has once again reminded us the importance of understanding infectious diseases. One important but understudied area in infectious disease research is the role of nuclear architecture or the physical arrangement of the genome in the nucleus in controlling gene regulation and pathogenicity. Recent advances in research methods, such as Genome-wide chromosome conformation capture using high-throughput sequencing (Hi-C), have allowed for easier analysis of nuclear architecture and chromosomal reorganization in both the infectious disease agents themselves as well as in their host cells. This review will discuss broadly on what is known about nuclear architecture in infectious disease, with an emphasis on chromosomal reorganization, and briefly discuss what steps are required next in the field.
  • |Animals[MESH]
  • |COVID-19/genetics/metabolism[MESH]
  • |Cell Nucleus/*genetics/metabolism[MESH]
  • |Chromatin/genetics/*metabolism[MESH]
  • |Chromosomes/genetics/metabolism[MESH]
  • |Communicable Diseases/*genetics/metabolism[MESH]
  • |Gene Expression Regulation[MESH]


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