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10.1371/journal.pone.0246295 http://scihub22266oqcxt.onion/10.1371/journal.pone.0246295 33539383!7861397!33539383     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33539383&cmd=llinks): Failed to open stream: HTTP request failed! 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Hematological and biochemical abnormalities associated with severe forms of COVID-19: A retrospective single-center study from Morocco |pdf=|usr=}}{{33539383}} gab.com Text Hematological and biochemical abnormalities associated with severe forms of COVID-19: A retrospective single-center study from Morocco JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=33539383 #FOAvip Since December 2019, the coronavirus disease (COVID-19) pandemic has catapulted the world into a marked health crisis, with over 29 million cases and >930,000 deaths. To better detect affected individuals at an early stage and stop disease progression to an advanced stage, several studies have been conducted to identify the clinical, biological, and radiological characteristics of COVID-19. This study aimed to enrich the literature by critically analyzing the clinical and biological characteristics of 134 patients from the North African Mediterranean region, including numerous genetic, epigenetic, and environmental factors that may influence disease evolution. This single-center retrospective study included all patients older than 18 years confirmed to have COVID-19 and hospitalized at the Cheikh Khalifa University Hospital affiliated with Mohammed VI University of Health Sciences, Casablanca, Morocco. Clinical, demographic, and biological data were analyzed in a cohort of severe and non-severe patients. Univariate analysis was performed to identify factors predictive of severity. There were 134 patients: the median age was 53 years, and 54.5% were male. Of these, 89 had mild to moderate disease; 45 had severe to critical disease, of which 14 died and 31 survived. Advanced age, presence of comorbidities, male sex, and infection in ethnic or family groups were risk factors for progression to severe disease. The presence of abnormalities in the following parameters were strongly associated with progression to severe disease: white blood cells (WBC), neutrophils, lymphocytes, C-reactive protein (CRP), procalcitonin, D-dimers, lactate dehydrogenase (LDH), ferritin, creatinine, aspartate aminotransferase (ASAT), and alanine aminotransferase (ALAT) during both admission and hospitalization. Based on these results and an extensive literature review, we recommend that clinicians closely monitor the biological parameters identified herein and perform immunological and genetic studies. Twit Text FOAVip Hematological and biochemical abnormalities associated with severe forms of COVID-19: A retrospective single-center study from Morocco ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=33539383 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33539383 #FOAvip English Wikipedia <ref>{{Cite pmid|33539383}}</ref> Hematological and biochemical abnormalities associated with severe forms of COVID-19: A retrospective single-center study from Morocco #MMPMID33539383 Kantri A; Ziati J; Khalis M; Haoudar A; El Aidaoui K; Daoudi Y; Chikhaoui I; El Yamani K; Mouhaoui M; El Bakkouri J; Dini N; Mahi M; Naitlho A; Bahlaoui A; Bennana A; Noussair M; Belyamani L; El Kettani C PLoS One 2021[]; 16 (2): e0246295 PMID33539383show ga Since December 2019, the coronavirus disease (COVID-19) pandemic has catapulted the world into a marked health crisis, with over 29 million cases and >930,000 deaths. To better detect affected individuals at an early stage and stop disease progression to an advanced stage, several studies have been conducted to identify the clinical, biological, and radiological characteristics of COVID-19. This study aimed to enrich the literature by critically analyzing the clinical and biological characteristics of 134 patients from the North African Mediterranean region, including numerous genetic, epigenetic, and environmental factors that may influence disease evolution. This single-center retrospective study included all patients older than 18 years confirmed to have COVID-19 and hospitalized at the Cheikh Khalifa University Hospital affiliated with Mohammed VI University of Health Sciences, Casablanca, Morocco. Clinical, demographic, and biological data were analyzed in a cohort of severe and non-severe patients. Univariate analysis was performed to identify factors predictive of severity. There were 134 patients: the median age was 53 years, and 54.5% were male. Of these, 89 had mild to moderate disease; 45 had severe to critical disease, of which 14 died and 31 survived. Advanced age, presence of comorbidities, male sex, and infection in ethnic or family groups were risk factors for progression to severe disease. The presence of abnormalities in the following parameters were strongly associated with progression to severe disease: white blood cells (WBC), neutrophils, lymphocytes, C-reactive protein (CRP), procalcitonin, D-dimers, lactate dehydrogenase (LDH), ferritin, creatinine, aspartate aminotransferase (ASAT), and alanine aminotransferase (ALAT) during both admission and hospitalization. Based on these results and an extensive literature review, we recommend that clinicians closely monitor the biological parameters identified herein and perform immunological and genetic studies. |Adult[MESH] |Aged[MESH] |COVID-19/*blood/diagnosis/epidemiology[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Morocco/epidemiology[MESH] |Retrospective Studies[MESH] |SARS-CoV-2/*isolation & purification[MESH]Hematological and biochemical abnormalities associated with severe for(epmc).pdf DeepDyve Pubget Overpricing