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10.1093/intimm/dxab005 http://scihub22266oqcxt.onion/10.1093/intimm/dxab005 33538817!7928855!33538817     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+Immunol 2021 ; 33 (4): 241-247 Nephropedia Template TP {{tp|p=33538817|t=2021. Myeloid cell dynamics correlating with clinical outcomes of severe COVID-19 in Japan |pdf=|usr=}}{{33538817}} gab.com Text Myeloid cell dynamics correlating with clinical outcomes of severe COVID-19 in Japan JO: Int Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33538817 #FOAvip An expanded myeloid cell compartment is a hallmark of severe coronavirus disease 2019 (COVID-19). However, data regarding myeloid cell expansion have been collected in Europe, where the mortality rate by COVID-19 is greater than those in other regions including Japan. Thus, characteristics of COVID-19-induced myeloid cell subsets remain largely unknown in the regions with low mortality rates. Here, we analyzed cellular dynamics of myeloid-derived suppressor cell (MDSC) subsets and examined whether any of them correlate with disease severity and prognosis, using blood samples from Japanese COVID-19 patients. We observed that polymorphonuclear (PMN)-MDSCs, but not other MDSC subsets, transiently expanded in severe cases but not in mild or moderate cases. Contrary to previous studies in Europe, this subset selectively expanded in survivors of severe cases and subsided before discharge, but such transient expansion was not observed in non-survivors in Japanese cohort. Analysis of plasma cytokine/chemokine levels revealed positive correlation of PMN-MDSC frequencies with IL-8 levels, indicating the involvement of IL-8 on recruitment of PMN-MDSCs to peripheral blood following the onset of severe COVID-19. Our data indicate that transient expansion of the PMN-MDSC subset results in improved clinical outcome. Thus, this myeloid cell subset may be a predictor of prognosis in cases of severe COVID-19 in Japan. Twit Text FOAVip Myeloid cell dynamics correlating with clinical outcomes of severe COVID-19 in Japan ????Int Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33538817 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33538817 #FOAvip English Wikipedia <ref>{{Cite pmid|33538817}}</ref> Myeloid cell dynamics correlating with clinical outcomes of severe COVID-19 in Japan #MMPMID33538817 Takano T; Matsumura T; Adachi Y; Terahara K; Moriyama S; Onodera T; Nishiyama A; Kawana-Tachikawa A; Miki S; Hosoya-Nakayama K; Nakamura-Hoshi M; Seki S; Tachikawa N; Yoshimura Y; Miyata N; Horiuchi H; Sasaki H; Miyazaki K; Kinoshita N; Sudo T; Akiyama Y; Sato R; Suzuki T; Matano T; Takahashi Y Int Immunol 2021[Mar]; 33 (4): 241-247 PMID33538817show ga An expanded myeloid cell compartment is a hallmark of severe coronavirus disease 2019 (COVID-19). However, data regarding myeloid cell expansion have been collected in Europe, where the mortality rate by COVID-19 is greater than those in other regions including Japan. Thus, characteristics of COVID-19-induced myeloid cell subsets remain largely unknown in the regions with low mortality rates. Here, we analyzed cellular dynamics of myeloid-derived suppressor cell (MDSC) subsets and examined whether any of them correlate with disease severity and prognosis, using blood samples from Japanese COVID-19 patients. We observed that polymorphonuclear (PMN)-MDSCs, but not other MDSC subsets, transiently expanded in severe cases but not in mild or moderate cases. Contrary to previous studies in Europe, this subset selectively expanded in survivors of severe cases and subsided before discharge, but such transient expansion was not observed in non-survivors in Japanese cohort. Analysis of plasma cytokine/chemokine levels revealed positive correlation of PMN-MDSC frequencies with IL-8 levels, indicating the involvement of IL-8 on recruitment of PMN-MDSCs to peripheral blood following the onset of severe COVID-19. Our data indicate that transient expansion of the PMN-MDSC subset results in improved clinical outcome. Thus, this myeloid cell subset may be a predictor of prognosis in cases of severe COVID-19 in Japan. |COVID-19/*pathology[MESH] |Humans[MESH] |Interleukin-8/*blood/immunology[MESH] |Japan[MESH] |Leukocyte Count[MESH] |Myeloid Cells/immunology[MESH] |Myeloid-Derived Suppressor Cells/*immunology[MESH] |Neutrophil Activation/immunology[MESH] |Neutrophils/*immunology[MESH]Myeloid cell dynamics correlating with clinical outcomes of severe COV(epmc).pdf DeepDyve Pubget Overpricing