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Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Bioanalysis 2021 ; 13 (3): 161-167 Nephropedia Template TP
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Adaptation of Elecsys((R)) anti-severe acute respiratory syndrome coronavirus-2 immunoassay to dried blood spots: proof of concept #MMPMID33538622
Marchand A; Roulland I; Semence F; Ericsson M
Bioanalysis 2021[Feb]; 13 (3): 161-167 PMID33538622show ga
Aim: Several automated immunoassays have been validated on serum/plasma to evaluate the presence of significant levels of anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) antibodies, signs of a present or past infection, but the use of dried blood spots (DBS) would facilitate sampling, shipping and storage. Objective: The aim of this project was to give proof of concept of the possibility to use of the automatized Elecsys((R)) anti-SARS-CoV-2 immunoassay with a volumetric DBS device. Results: Linearity and correlation were satisfactory between volumetric DBS and plasma. A cut-off value was suggested and should be validated with more samples. Conclusion: this study strongly support the possibility to work with volumetric DBS instead of serum/plasma to test for anti-SARS-CoV-2 antibodies.