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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Future+Oncol 2021 ; 17 (9): 1097-1104 Nephropedia Template TP
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The right immune-modulation at the right time: thymosin alpha1 for prevention of severe COVID-19 in cancer patients #MMPMID33538178
Bersanelli M; Giannarelli D; Leonetti A; Buti S; Tiseo M; Nouvenne A; Ticinesi A; Meschi T; Procopio G; Danielli R
Future Oncol 2021[Mar]; 17 (9): 1097-1104 PMID33538178show ga
We presented the rationale for the use of thymosin alpha1 as prophylaxis of severe COVID-19 in cancer patients undergoing active treatment, constituting the background for the PROTHYMOS study, a prospective, multicenter, open-label, Phase II randomized study, currently in its start-up phase (Eudract no. 2020-006020-13). We aim to offer new hope for this incurable disease, especially to frail patient population, such as patients with cancer. The hypothesis of an effective prophylactic approach to COVID-19 would have immediate clinical relevance, especially given the lack of curative approaches. Moreover, in the 'COVID-19 vaccine race era' both clinical and biological results coming from the PROTHYMOS trials could even support the rationale for future combinatorial approaches, trying to rise vaccine efficacy in frail individuals.