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10.1038/s41598-021-82389-9 http://scihub22266oqcxt.onion/10.1038/s41598-021-82389-9 33536488!7859212!33536488     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2021 ; 11 (1): 2909 Nephropedia Template TP {{tp|p=33536488|t=2021. Low birth weight as a potential risk factor for severe COVID-19 in adults |pdf=|usr=}}{{33536488}} gab.com Text Low birth weight as a potential risk factor for severe COVID-19 in adults JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33536488 #FOAvip The identification of factors predisposing to severe COVID-19 in young adults remains partially characterized. Low birth weight (LBW) alters cardiovascular and lung development and predisposes to adult disease. We hypothesized that LBW is a risk factor for severe COVID-19 in non-elderly subjects. We analyzed a prospective cohort of 397 patients (18-70 years) with laboratory-confirmed SARS-CoV-2 infection attended in a tertiary hospital, where 15% required admission to Intensive Care Unit (ICU). Perinatal and current potentially predictive variables were obtained from all patients and LBW was defined as birth weight </= 2.500 g. Age (adjusted OR (aOR) 1.04 [1-1.07], P = 0.012), male sex (aOR 3.39 [1.72-6.67], P < 0.001), hypertension (aOR 3.37 [1.69-6.72], P = 0.001), and LBW (aOR 3.61 [1.55-8.43], P = 0.003) independently predicted admission to ICU. The area under the receiver-operating characteristics curve (AUC) of this model was 0.79 [95% CI, 0.74-0.85], with positive and negative predictive values of 29.1% and 97.6% respectively. Results were reproduced in an independent cohort, from a web-based survey in 1822 subjects who self-reported laboratory-positive SARS-CoV-2 infection, where 46 patients (2.5%) needed ICU admission (AUC 0.74 [95% CI 0.68-0.81]). LBW seems to be an independent risk factor for severe COVID-19 in non-elderly adults and might improve the performance of risk stratification algorithms. Twit Text FOAVip Low birth weight as a potential risk factor for severe COVID-19 in adults ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33536488 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33536488 #FOAvip English Wikipedia <ref>{{Cite pmid|33536488}}</ref> Low birth weight as a potential risk factor for severe COVID-19 in adults #MMPMID33536488 Crispi F; Crovetto F; Larroya M; Camacho M; Tortajada M; Sibila O; Badia JR; Lopez M; Vellve K; Garcia F; Trilla A; Faner R; Blanco I; Borras R; Agusti A; Gratacos E Sci Rep 2021[Feb]; 11 (1): 2909 PMID33536488show ga The identification of factors predisposing to severe COVID-19 in young adults remains partially characterized. Low birth weight (LBW) alters cardiovascular and lung development and predisposes to adult disease. We hypothesized that LBW is a risk factor for severe COVID-19 in non-elderly subjects. We analyzed a prospective cohort of 397 patients (18-70 years) with laboratory-confirmed SARS-CoV-2 infection attended in a tertiary hospital, where 15% required admission to Intensive Care Unit (ICU). Perinatal and current potentially predictive variables were obtained from all patients and LBW was defined as birth weight |*Infant, Low Birth Weight[MESH] |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Area Under Curve[MESH] |COVID-19/*pathology/virology[MESH] |Female[MESH] |Humans[MESH] |Intensive Care Units/statistics & numerical data[MESH] |Logistic Models[MESH] |Male[MESH] |Middle Aged[MESH] |Prospective Studies[MESH] |ROC Curve[MESH] |Risk Factors[MESH] |SARS-CoV-2/isolation & purification[MESH] |Self Report[MESH] |Severity of Illness Index[MESH] |Surveys and Questionnaires[MESH] |Tertiary Care Centers[MESH]Low birth weight as a potential risk factor for severe COVID-19 in adu(epmc).pdf DeepDyve Pubget Overpricing