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10.1038/s41467-021-21037-2 http://scihub22266oqcxt.onion/10.1038/s41467-021-21037-2 33536425!7858593!33536425     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 776 Nephropedia Template TP {{tp|p=33536425|t=2021. A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS-CoV-2 |pdf=|usr=}}{{33536425}} gab.com Text A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS-CoV-2 JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33536425 #FOAvip The rapid expansion of the COVID-19 pandemic has made the development of a SARS-CoV-2 vaccine a global health and economic priority. Taking advantage of versatility and rapid development, three SARS-CoV-2 mRNA vaccine candidates have entered clinical trials with a two-dose immunization regimen. However, the waning antibody response in convalescent patients after SARS-CoV-2 infection and the emergence of human re-infection have raised widespread concerns about a possible short duration of SARS-CoV-2 vaccine protection. Here, we developed a nucleoside-modified mRNA vaccine in lipid-encapsulated form that encoded the SARS-CoV-2 RBD, termed as mRNA-RBD. A single immunization of mRNA-RBD elicited both robust neutralizing antibody and cellular responses, and conferred a near-complete protection against wild SARS-CoV-2 infection in the lungs of hACE2 transgenic mice. Noticeably, the high levels of neutralizing antibodies in BALB/c mice induced by mRNA-RBD vaccination were maintained for at least 6.5 months and conferred a long-term notable protection for hACE2 transgenic mice against SARS-CoV-2 infection in a sera transfer study. These data demonstrated that a single dose of mRNA-RBD provided long-term protection against SARS-CoV-2 challenge. Twit Text FOAVip A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS-CoV-2 ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33536425 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33536425 #FOAvip English Wikipedia <ref>{{Cite pmid|33536425}}</ref> A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS-CoV-2 #MMPMID33536425 Huang Q; Ji K; Tian S; Wang F; Huang B; Tong Z; Tan S; Hao J; Wang Q; Tan W; Gao GF; Yan J Nat Commun 2021[Feb]; 12 (1): 776 PMID33536425show ga The rapid expansion of the COVID-19 pandemic has made the development of a SARS-CoV-2 vaccine a global health and economic priority. Taking advantage of versatility and rapid development, three SARS-CoV-2 mRNA vaccine candidates have entered clinical trials with a two-dose immunization regimen. However, the waning antibody response in convalescent patients after SARS-CoV-2 infection and the emergence of human re-infection have raised widespread concerns about a possible short duration of SARS-CoV-2 vaccine protection. Here, we developed a nucleoside-modified mRNA vaccine in lipid-encapsulated form that encoded the SARS-CoV-2 RBD, termed as mRNA-RBD. A single immunization of mRNA-RBD elicited both robust neutralizing antibody and cellular responses, and conferred a near-complete protection against wild SARS-CoV-2 infection in the lungs of hACE2 transgenic mice. Noticeably, the high levels of neutralizing antibodies in BALB/c mice induced by mRNA-RBD vaccination were maintained for at least 6.5 months and conferred a long-term notable protection for hACE2 transgenic mice against SARS-CoV-2 infection in a sera transfer study. These data demonstrated that a single dose of mRNA-RBD provided long-term protection against SARS-CoV-2 challenge. |Angiotensin-Converting Enzyme 2/genetics/*immunology/metabolism[MESH] |Animals[MESH] |Antibodies, Neutralizing/immunology[MESH] |COVID-19 Vaccines/*administration & dosage/genetics/*immunology[MESH] |COVID-19/immunology/*prevention & control[MESH] |Cell Line[MESH] |Female[MESH] |Humans[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Mice, Inbred C57BL[MESH] |Mice, Transgenic[MESH] |Pandemics/prevention & control[MESH] |RNA, Messenger/genetics/immunology[MESH] |RNA, Viral/genetics/immunology[MESH] |SARS-CoV-2/*genetics/*immunology[MESH] |Spike Glycoprotein, Coronavirus/immunology/metabolism[MESH] |Vaccines, Synthetic/administration & dosage/genetics/immunology[MESH] |Viral Envelope Proteins/immunology[MESH]A single-dose mRNA vaccine provides a long-term protection for hACE2 t(epmc).pdf DeepDyve Pubget Overpricing